Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-14T18:16:16.019Z Has data issue: false hasContentIssue false
  • English
  • Français

Helical Rosette Nanotubes as a Potentially More Effective Orthopaedic Implant Material

Published online by Cambridge University Press:  01 February 2011

Ai Lin Chun ,
Hicham Fenniri  and
Thomas J. Webster
Ai Lin Chun
Affiliation:
Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907
Hicham Fenniri
Affiliation:
National Institute for Nanotechnology, National Research Council and the University of Alberta, Edmonton, Canada
Thomas J. Webster
Affiliation:
Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907
Get access

Abstract

Organic nanotubes called helical rosette nanotubes (HRN) have been synthesized in this study for bone tissue engineering applications. They possess intriguing properties for various bionanotechnology applications since they can be designed to mimic the nanostructured constituent components in bone such as collagen fibers and hydroxyapatite (Ca5(PO4)3(OH)) which bone cells are naturally accustomed to interacting with. This is in contrast to currently used orthopaedic materials such as titanium which do not possess desirable nanometer surface roughness. The objective of this in vitro study was to determine bone-forming cell (osteoblasts) interactions on titanium coated with HRNs. Results of this study showed for the first time increased osteoblast adhesion on titanium coated with HRNs compared to those not coated with HRNs. In this manner, this study provided evidence that HRNs should be further considered for orthopaedic applications.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA1.3
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Fenniri, H., Deng, B.L., Ribbe, A. E., J. Am. Chem. Soc. 124, 11064–11072, 2002.Google Scholar
2. Fenniri, H., Deng, B.L., Ribbe, A.E., Jacob, J., Thyagarajan, P., Proc. Natl. Acad. Sci. USA 99, 6487–6492, 2002. See also C & E News: R. Dagani, 80 (11), 9, 2002.Google Scholar
3. Fenniri, H., Mathiavanan, P., Vidale, K.L., Sherman, D.M., Hallenga, K., Wood, K.V., Stowell, J.G., J. Am. Chem. Soc. 123, 3854–3855, 2001.Google Scholar
4. Fenniri, H., Packiarajan, M., Ribbe, A.E., Vidale, K.E., Polym. Preprints, 42, 569–570, 2001. Google Scholar
5. Webster, T.J., Nanophase ceramics. In: The future orthopedic and dental implant material, Advances in Chemical Engineering Vol. 27 (Ying, J.Y., editor), Academic Press, NY, pgs. 125–166, 2001.Google Scholar
6. Webster, T.J., Siegel, R.W., Bizios, R., Biomaterials 21, 1803–1810, 2000. See also C& E News: R. Dagani, Feb 28. 39-42, 2002.Google Scholar