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Novel Collagen Based Material for Local Drug Delivery Systems

Published online by Cambridge University Press:  01 February 2011

Luciano Castaneda ,
Suzanne Pluskat ,
Darline Ky ,
Earry Te  and
Katarzyna Slowinska
Luciano Castaneda
Affiliation:
kuslowin@csulb.edu, California State University, Long Beach, Chemistry and Biochemistry, 1250 Bellflower Blvd, Long Beach, CA, 90840-3903, United States
Suzanne Pluskat
Affiliation:
kuslowin@csulb.edu, California State University, Long Beach, Long Beach, CA, 90840-3903, United States
Darline Ky
Affiliation:
kuslowin@csulb.edu, California State University, Long Beach, Long Beach, CA, 90840-3903, United States
Earry Te
Affiliation:
kuslowin@csulb.edu, California State University, Long Beach, Long Beach, CA, 90840-3903, United States
Katarzyna Slowinska
Affiliation:
kuslowin@csulb.edu, California State University, Long Beach, Long Beach, CA, 90840-3903, United States
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Abstract

In a search for new drug delivery matrix, the synthesis of a novel collagen material based on tiopronin protected gold clusters (MPC) as a crosslinking agent is proposed. The structure of collagen matrix modified with MPC is studied using transmission electron microscope. The thermal properties are examined with differential scanning calorimetry. To assess the biocompatibility of the matrix, the cytotoxicity assays are conducted.

Keywords

biomaterialcalorimetrytransmission electron microscopy (TEM)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1008: Symposium T – The Nature of Design-Utilizing Biology's Portfolio , 2007 , 1008-T09-08
Copyright
Copyright © Materials Research Society 2007

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References

1. Wallace, D.G., Rosenblatt, J., Adv. Drug Delivery Rev. 55, 1631–1549 (2003)Google Scholar
2. Sano, A., Maeda, M., Nagahara, S., Ochiya, T., Honma, K., Itoh, H., Miyata, T., Fujioka, K., Adv. Drug Delivery Rev. 55, 1651–1677 (2003)Google Scholar
3. Bateman, J.F., Lamande, S. and Ramshaw, J.A.M., Collagen superfamily. In: W.D. Comper Ed., Extracellular Matrix: Vol. 2, Molecular Components and Interactions, Harwood Academic Publishers, Amsterdam, pp. 22–67 (1995)Google Scholar
4. Ruszczak, Z., Friess, W., Drug Delivery Rev. 55, 1679–1698 (2003)Google Scholar
5. Ho, H.O., Lin, C.W., Sheu, M.T., J. Control. Release 77, 97–105 (2001)Google Scholar
6. Housley, T.J., Tanzer, M.L., Henson, E., Gallop, P.M., Biochem. Biophys. Res. Commun. 67, 824–829 (1975)Google Scholar
7. Duan, X., Sheardown, H., J. Biomed. Mater.Res. A, 75, 510–518 (2005)Google Scholar
8. Brust, M., Walker, M., Bethell, D., Schiffrin, D.J., Whyman, R., J. Chem. Soc. Chem. Commun. 801–802 (1994)Google Scholar
9. Templeton, A.C., Chen, S., Gross, S.M., Murray, R.W., Langmuir, 15, 66–76 (1998)Google Scholar
10. Ho, H.O., Lin, L.H., Sheu, M.T., J. Control. Release 44, 103–112 (1997)Google Scholar
11. Giron, D., J. Therm. Anal. Cal. 56, 1285–1304 (1999)Google Scholar
12. Mrevlishvili, G.M., Svintradze, D.W., Int. J. Biol. Macromol. 35, 243–245 (2005)Google Scholar
13. Wise, D.L., Biomaterials and bioengineering handbook, Marcel Dekker, NY, (2000)Google Scholar
14. Spector, D.L., Goldman, R.D., Leinwand, L.A., A, Cells. laboratory manual. Vol I: Culture and biochemical analysis of cells, Cold Spring Harbor Laboratory Press, (1998).Google Scholar