Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-28T16:57:53.120Z Has data issue: false hasContentIssue false
  • English
  • Français

Preparation of drug delivery biodegradable PLGA nanocomposites and foams by supercritical CO2 expanded ring opening polymerization and by rapid expansion from CHCIF2 supercritical solutions

Published online by Cambridge University Press:  01 February 2011

Alexandru D. Asandei ,
Can Erkey ,
Diane J. Burgess ,
Carl Saquing ,
Gobinda Saha  and
Banu S. Zolnik
Alexandru D. Asandei
Affiliation:
Institute of Materials Science, Polymer Program, University of Connecticut, Storrs, CT 06269 Department of Chemistry, University of Connecticut, Storrs, CT 06269
Can Erkey
Affiliation:
Department of Chemical Engineering, University of Connecticut, Storrs, CT 06269
Diane J. Burgess
Affiliation:
School of Pharmacy, University of Connecticut, Storrs, CT 06269
Carl Saquing
Affiliation:
Department of Chemical Engineering, University of Connecticut, Storrs, CT 06269
Gobinda Saha
Affiliation:
Institute of Materials Science, Polymer Program, University of Connecticut, Storrs, CT 06269
Banu S. Zolnik
Affiliation:
School of Pharmacy, University of Connecticut, Storrs, CT 06269
Get access

Abstract

The synthesis of poly(lactic-co-glycolic acid) (PLGA) by the ring opening copolymerization of D, L-lactide and glycolide was performed at 110 °C to 130 °C using Sn(Oct)2 as catalyst, 1, 10-decanediol as initiator in a supercritical sc-CO2 expanded medium at pressures of up to 3, 500 psi. Due to the limited monomer solubility in sc-CO2 at low temperatures (70 °C), only Mn = 2, 500 is typically obtained. However, molecular weight increases with both temperature and sc-CO2 pressure. Thus, Mn = 13, 000 (PDI = 1.28) was obtained at 110 °C - 130 °C even in the absence of fluorinated surfactants. Biodegradable drug delivery nanocomposites based on dexamethasone and poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) were prepared by the rapid expansion of the corresponding supercritical CHClF2 solutions (110 °C, 200-300 bar) in air (RESS) and in toluene (RESOLV). The RESS process leads to a broad particle size distribution (100-500 nm) while the RESOLV generates a narrower distribution centered around 100 nm and is accompanied by the formation of a few large particles, most likely due to aggregation.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.7
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Burgess, D. J. and Hickey, A. J. Microsphere Technology and Applications: In “Encyclopedia of Pharmaceutical Technology” Swarbrick, J., Boylan, J.C., Eds.; Marcel Dekker, Inc., New York and Basel, 10, 1 (1994).Google Scholar
2. Wells, S. L. and DeSimone, J. M., Angew. Chem. Int. Ed. 40, 518 (2001).Google Scholar
3. Liu, Z. and Erkey, C., Langmuir 17, 274 (2001).Google Scholar
4. (a) Asandei, A. D., Erkey, C., Burgess, D. J., Saquing, C., Saha, G. and Zolnik, B. S. Polym. Prepr. 45(1), 1014 (2004).Google Scholar
(b) Asandei, A. D., Moran, I. W., Saha, G. and Chen, Y., Polymer. Mater.: Sci. Eng. 91, 786 (2004).Google Scholar
5. (a) Hile, D. D. and Pishko, M. V., Macromol. Rapid Commun. 20, 511 (1999)Google Scholar
(b) Hile, D. D. and Pishko, M. V., J. Polym. Sci.: Part A: Polym. Chem. 39, 562 (2001).Google Scholar
(c) Conway, S. E., Byun, H. S., McHugh, M. A., Wang, J. D. and Mandel, F.S., J. Appl. Polym. Sci. 80, 1155 (2001).Google Scholar
6. Jung, J. and Perrut, M., J. Supercrit. Fluids 20, 179 (2001).Google Scholar
7. Meziani, M. J., Pathak, P., Hurezeanu, R., Thies, M. C., Enick, R. M. and Sun, Y. P., Angew. Chem. Int. Ed. 43, 704 (2004).Google Scholar
8. Kricheldorf, H. R. and Kreiser, I., Makromol. Chem. 188, 1861 (1987).Google Scholar