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Synthesis and Characterization of Magnetic Polymeric Nanospheres for Biomedical Applications

Published online by Cambridge University Press:  11 February 2011

D. K. Kim ,
M. Mikhaylova ,
M. Toprak ,
A. Guyou ,
Y. K. Jeong  and
M. Muhammed
D. K. Kim
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Mikhaylova
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
M. Toprak
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
A. Guyou
Affiliation:
Institut des Science et Techniques de Grenoble, France
Y. K. Jeong
Affiliation:
KICET (Korea Institute of Ceramic Engineering and Technology) 153–801, Seoul, Korea
M. Muhammed
Affiliation:
Materials Chemistry Division, Royal Institute of Technology, SE-100 44 Stockholm, Sweden
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Abstract

Entrapment of proteins in biodegradable nanospheres has been widely investigated as a technique to produce sustained release formulations for protein or anti-cancer drugs administration. Amphiphilic PLLA-mPEG diblock copolymer was prepared by ring opening polymerization (ROP) to form polymeric nanoparticles with a core-shell structure. The main encapsulation technique done is a water-in-oil-in-water (w/o/w) solvent evaporation technique. Here, protein was encapsulated using a newly developed water-in-oil emulsion-solvent diffusion technique. This technique leads to the formation of an emulsion combined with the immediate precipitation of the PLLA-mPEG. This phenomenon is caused by the diffusion of the polymer solvent to an external organic phase.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 750: Symposium Y – Surface Engineering 2002–Synthesis, Characterization and Applications , 2002 , Y9.2
Copyright
Copyright © Materials Research Society 2003

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References

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