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Glucagon-like peptide-1 regulation by food proteins and protein hydrolysates

Published online by Cambridge University Press:  19 January 2021

Alba Miguéns-Gómez ,
Àngela Casanova-Martí ,
M. Teresa Blay ,
Ximena Terra ,
Raúl Beltrán-Debón ,
Esther Rodríguez-Gallego ,
Anna Ardévol Open the ORCID record for Anna Ardévol [Opens in a new window]  and
Montserrat Pinent
Alba Miguéns-Gómez
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Àngela Casanova-Martí
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
M. Teresa Blay
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Ximena Terra
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Raúl Beltrán-Debón
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Esther Rodríguez-Gallego
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Anna Ardévol*
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
Montserrat Pinent
Affiliation:
MoBioFood Research Group, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain
*
*Corresponding author: Anna Ardévol, email anna.ardevol@urv.cat
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Abstract

Glucagon-like peptide-1 (GLP-1) is an enterohormone with a key role in several processes controlling body homeostasis, including glucose homeostasis and food intake regulation. It is secreted by the intestinal cells in response to nutrients, such as glucose, fat and amino acids. In the present review, we analyse the effect of protein on GLP-1 secretion and clearance. We review the literature on the GLP-1 secretory effects of protein and protein hydrolysates, and the mechanisms through which they exert these effects. We also review the studies on protein from different sources that has inhibitory effects on dipeptidyl peptidase-4 (DPP4), the enzyme responsible for GLP-1 inactivation, with particular emphasis on specific sources and treatments, and the gaps there still are in knowledge. There is evidence that the protein source and the hydrolytic processing applied to them can influence the effects on GLP-1 signalling. The gastrointestinal digestion of proteins, for example, significantly changes their effectiveness at modulating this enterohormone secretion in both in vivo and in vitro studies. Nevertheless, little information is available regarding human studies and more research is required to understand their potential as regulators of glucose homeostasis.

Keywords

EnterohormonesGlucagon-like peptide-1Dietary proteinHydrolysatesSecretagogues
Type
Review Article
Information
Nutrition Research Reviews , Volume 34 , Issue 2 , December 2021 , pp. 259 - 275
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Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to the present review.

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