Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-18T20:30:50.306Z Has data issue: false hasContentIssue false
  • English
  • Français

Homologous and heterologous resistance in Echinostoma revolutum infections in mice

Published online by Cambridge University Press:  06 April 2009

S. B. Sirag ,
N. Ø. Christensen ,
F. Frandsen ,
J. Monrad  and
P. Nansen
S. B. Sirag
Affiliation:
Danish Bilharziasis Laboratory, Jægersborg Alle 1 D, DK-2920 Charlottenlund, Denmark
N. Ø. Christensen
Affiliation:
Danish Bilharziasis Laboratory, Jægersborg Alle 1 D, DK-2920 Charlottenlund, Denmark
F. Frandsen
Affiliation:
Danish Bilharziasis Laboratory, Jægersborg Alle 1 D, DK-2920 Charlottenlund, Denmark
J. Monrad
Affiliation:
Danish Bilharziasis Laboratory, Jægersborg Alle 1 D, DK-2920 Charlottenlund, Denmark
P. Nansen
Affiliation:
Institute of Veterinary Microbiology and Hygiene, Royal Veterinary and Agricultural University, Bulowsvej 13, DK-1810 Copenhagen V, Denmark
Get access Rights & Permissions [Opens in a new window]

Summary

Homologous and heterologous resistance in Echinostoma revolutum infections was studied in mice. A high level of homologous resistance was demonstrated in mice harbouring a 13-day-old primary E. revolutum infection with 9–10 and 11–15 worms, corresponding to a 70·0 and 66·7% reduction in the size of the established worm burden as compared with that of the challenge control group. A 14- and 20-day-old primary infection with 3–4 worms induced a level of resistance of 61·7 and 81·8% respectively, while higher worm levels of 9–10 and 11–15 induced almost complete resistance corresponding to a 95·1–100% reduction in the size of the established worm burden. Complete resistance was also demonstrated in mice challenged 8 days after elimination of a 20-day-old primary infection with 11–15 worms by anthelmintic treatment. A primary 43-day-old Schistosoma mansoni infection induced a 73·1% reduction in the size of the established E. revolutum challenge infection while infections of an age of 79 and 99 days conferred complete resistance to heterologous challenge with E. revolutum. Primary pre-patent S. mansoni infections and a patent S. bovis infection of an age of 56 days did not induce any resistance to challenge with E. revolutum. A primary 14- and 21-day-old infection of E. revolutum did not stimulate any significant level of resistance to heterologous challenge with S. mansoni.

Type
Research Article
Information
Parasitology , Volume 80 , Issue 3 , June 1980 , pp. 479 - 486
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beaver, P. C. (1937). Experimental studies on Echinostoma revolutum (Froelich) a fluke from birds and mammals. Illinois Biological Monographs 15, 1–96.Google Scholar
Preston, J. M. & James, C. (1972). Infection of hamsters with terminal-spined schistosomes. Journal of Helminthology 47, 291–6.CrossRefGoogle Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Taylor, M. G., Nelson, G. S., Smith, M. & Andrews, R. J. (1973). Studies on heterologous immunity in Schistosomiasis. 7. Observations on the development of acquired homologous and heterologous immunity to Schistosoma mansoni in baboons. Bulletin of the World Health Organization 49, 57–65.Google ScholarPubMed
Wakelin, D. (1976). Host responses. In Ecological Aspects of Parasitology (ed. Kennedy, C. R.) pp. 114–41. Amsterdam: North-Holland Publishing Company.Google Scholar