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Phagocyte-specific S100 proteins in the local response to the Echinococcus granulosus larva

Published online by Cambridge University Press:  05 January 2012

TATIANA BASIKA ,
NATALIA MUÑOZ ,
CECILIA CASARAVILLA ,
FLORENCIA IRIGOÍN ,
CARLOS BATTHYÁNY ,
MARIANA BONILLA ,
GUSTAVO SALINAS ,
JOSÉ PEDRO PACHECO ,
JOHANESS ROTH  and
ROSARIO DURÁN
...Show all authors
TATIANA BASIKA
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
NATALIA MUÑOZ
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
CECILIA CASARAVILLA
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
FLORENCIA IRIGOÍN
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
CARLOS BATTHYÁNY
Affiliation:
Unidad de Bioquímica y Proteómica Analíticas, Instituto Pasteur de Montevideo, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay
MARIANA BONILLA
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
GUSTAVO SALINAS
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
JOSÉ PEDRO PACHECO
Affiliation:
Departamento de Patología, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay
JOHANESS ROTH
Affiliation:
Department of Dermatology, University of Münster, Münster, Germany
ROSARIO DURÁN
Affiliation:
Unidad de Bioquímica y Proteómica Analíticas, Instituto Pasteur de Montevideo, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay
ALVARO DÍAZ*
Affiliation:
Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay
*
*Corresponding author: Cátedra de Inmunología, Instituto de Higiene, Avenida Alfredo Navarro 3051, Montevideo, CP 11600, Uruguay. Tel/Fax: +59824874320. E-mail: adiaz@fq.edu.uy.
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Summary

Infection by larval Echinococcus granulosus is usually characterized by tight inflammatory control. However, various degrees of chronic granulomatous inflammation are also observed, reaching a high point in infection of cattle by the most prevalent parasite strain worldwide, which is not well adapted to this host species. In this context, epithelioid and multinucleated giant macrophages surround the parasite, and the secreted products of these cells often associate with the larval wall. The phagocyte-specific S100 proteins, S100A8, S100A9 and S100A12, are important non-conventionally secreted amplifiers of inflammatory responses. We have analysed by proteomics and immunohistochemistry the presence of these proteins at the E. granulosus larva-host interface. We found that, in the context of inflammatory control as observed in human infections, the S100 proteins are not abundant, but S100A9 and S100A8 can be expressed by eosinophils distal to the parasite. In the granulomatous inflammation context as observed in cattle infections, we found that S100A12 is one of the most abundant host-derived, parasite-associated proteins, while S100A9 and S100A8 are not present at similarly high levels. As expected, S100A12 derives mostly from the epithelioid and multinucleated giant cells. S100A12, as well as cathepsin K and matrix metalloproteinase-9, also expressed by E. granulosus-elicited epithelioid cells, are connected to the Th17 arm of immunity, which may therefore be involved in this granulomatous response.

Keywords

Echinococcus granulosusS100 proteinsgranulomacathepsin Kmetalloproteinase-9
Type
Research Article
Information
Parasitology , Volume 139 , Issue 2 , February 2012 , pp. 271 - 283
Copyright
Copyright © Cambridge University Press 2012

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