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Probing Trypanosoma cruzi biology with DNA microarrays

Published online by Cambridge University Press:  12 May 2005

B. A. BURLEIGH
B. A. BURLEIGH
Affiliation:
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntingzon Ave, Boston, MA 02115, USA
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Abstract

The application of genome-scale approaches to study Trypanosoma cruzi–host interactions at different stages of the infective process is becoming possible with sequencing and assembly of the T. cruzi genome nearing completion and sequence information available for both human and mouse genomes. Investigators have recently begun to exploit DNA microarray technology to analyze host transcriptional responses to T. cruzi infection and dissect developmental processes in the complex T. cruzi life-cycle. Collectively, information generated from these and future studies will provide valuable insights into the molecular requirements for establishment of T. cruzi infection in the host and highlight the molecular events coinciding with disease progression. While the field is in its infancy, the availability of genomic information and increased accessibility to relatively high-throughput technologies represents a significant advancement toward identification of novel drug targets and vaccine candidates for the treatment and prevention of Chagas' disease.

Keywords

Host responsetrypanosomemicroarrayChagas' diseasedifferentiation
Type
Research Article
Information
Parasitology , Volume 128 , Issue S1 , October 2004 , pp. S3 - S10
Copyright
© 2004 Cambridge University Press

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