Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-17T00:24:30.614Z Has data issue: false hasContentIssue false
  • English
  • Français

Acquired immunity to Babesia microti and Babesia rodhaini in mice

Published online by Cambridge University Press:  06 April 2009

F. E. G. Cox  and
A. S. Young
F. E. G. Cox
Affiliation:
Department of Zoology, University of London, King's College, Strand, London, W.C. 2
A. S. Young
Affiliation:
Department of Zoology, University of London, King's College, Strand, London, W.C. 2
Get access Rights & Permissions [Opens in a new window]

Extract

Mice infected with Babesia rodhaini can be cured with a single injection of Diampron and are immune to challenge with the same species. Mice infected with B. microti recover naturally from their infections and are also immune to challenge. The immunity extends to the heterologous species in both infections. In some cases parasites persist at a low level after recovery but in others the immunity is of a true sterile type. Immunity once established is unaffected by splenectomy in mice which have recovered from B. rodhaini and challenged with either B. rodhaini or B. microti.

We wish to express our thanks to May and Baker Ltd. who kindly provided us with the Diampron used in these experiments.

Type
Research Article
Information
Parasitology , Volume 59 , Issue 1 , February 1969 , pp. 257 - 268
Copyright
Copyright © Cambridge University Press 1969

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

van den Berghe, L., Vincke, I., Chardome, N. & van den Bulke, M. (1950). Babesia rodhaini n.sp. d'un rongeur du Congo Belge transmisible à la souris blanche. Annls Soc. beige Méd. trop. 30, 83–6.Google Scholar
Beveridge, E. (1953). Babesia rodhaini, a useful organism for the testing of drugs designed for the treatment of piroplasmosis. Ann. trop. Med. Parasit. 47, 134–8.CrossRefGoogle ScholarPubMed
Box, E. D. & Ginrich, W. D. (1958). Acquired immunity to Plasmodium berghei in the white mouse. J. infect. Dis. 103, 291–300.CrossRefGoogle ScholarPubMed
Callow, L. L. (1964). Strain immunity in babesiosis. Nature, Lond. 204, 1213–14.CrossRefGoogle ScholarPubMed
Colas-Belcour, J. & Vervent, G. (1953). Quelques observations sur des souris ayant survécu a leur infection par Babesia (Nuttallia) rodhaini van den Berghe, Vincke, Chardome et van den Bulcke 1950. Bull. Soc. Path. exot. 46, 34–9.Google Scholar
Corradetti, A. (1963). Acquired sterile immunity in experimental protozoal infections. In Immunity to Protozoa, pp. 69–77. Ed. Garnham, P. C. C., Pierce, A. E. and Roitt, I.. Oxford: Blackwell Scientific Publications.Google Scholar
Cox, F. E. G. (1966). Acquired immunity to Plasmodium vinckei in mice. Parasitology 56, 719–32.CrossRefGoogle ScholarPubMed
Cox, F. E. G. (1968). Immunity to tissue protozoa. In Immunity to Protozoa, pp. 5–23. Ed. Taylor, A. E. R.. Oxford: Blackwell Scientific Publications.Google Scholar
Cox, F. E. G. & Voller, A. (1966). Cross-immunity between the malaria parasites of rodents. Ann. trop. Med. Parasit. 60, 297–303.CrossRefGoogle ScholarPubMed
Fulton, J. D. & Lourie, E. M. (1946). The immunity of mice cured of trypanosome infections. Ann. trop. Med. Parasit. 40, 1–9.CrossRefGoogle ScholarPubMed
Galliard, H. & Cébe, J. (1941). Recherches sur les effets de la splénectomie chez le buffle en Tonkin. Rev. méd. fr. Extr.-Orient 18, 35–41.Google Scholar
Garnham, P. C. C. (1966). Malaria Parasites and other Haemosporidia. Oxford: Blackwell Scientific Publications.Google Scholar
Hoyte, H. M. D. (1961). Initial development of infection with Babesia bigemina. J. Protozool. 8, 462–6.CrossRefGoogle Scholar
Manwell, R. D. (1938). Reciprocal immunity in the avian malarias. Am. J. Hyg. 27, 196–211.Google Scholar
Miessner, H. (1931). Piroplasmosen und Splenektomie. Arch. wiss. prakt. Tierheilk. 63, 68–90.Google Scholar
Neitz, W. O. (1956). Classification, transmission and biology of piroplasms of domestic animals. Ann. N.Y. Acad. Sci. 64, 56–111.CrossRefGoogle Scholar
Paget, G. E., Alcock, S. & Ryley, J. F. (1962). The pathology of Babesia rodhaini infections in mice. J. Path. Bact. 84, 218–20.CrossRefGoogle ScholarPubMed
Riek, R. F. (1963). Immunity to babesiosis. In Immunity to Protozoa, pp. 160–79. Ed. Garnham, P. C. C., Pierce, A. E. and Roitt, I.. Oxford: Blackwell Scientific Publications.Google Scholar
Ryley, J. F. (1957). The chemotherapy of Babesia infections. Ann. trop. Med. Parasit. 51, 38–49.CrossRefGoogle ScholarPubMed
Schroeder, W. F., Cox, H. W. & Ristic, M. (1966). Anaemia, parasitaemia, erythrophagocytosis and haemmagglutinins in Babesia rodhaini infections. Ann. trop. Med. Parasit. 60, 31–8.CrossRefGoogle Scholar
Southgate, B. A. (1967). Studies on the epidemiology of East African leishmaniasis. 5. Leishmania adleri and natural immunity. J. trop. Med. Hyg. 70, 33–6.Google ScholarPubMed
Shortt, H. E. & Blackie, E. J. (1965). An account of the genus Babesia as found in certain small mammals in Britain. J. trop. Med. Hyg. 68, 37–42.Google ScholarPubMed