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Evasion of innate immunity by vaccinia virus

Published online by Cambridge University Press:  11 November 2005

I. R. HAGA  and
A. G. BOWIE
I. R. HAGA
Affiliation:
Department of Biochemistry, Trinity College, Dublin 2, Ireland
A. G. BOWIE
Affiliation:
Department of Biochemistry, Trinity College, Dublin 2, Ireland
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Abstract

Vaccinia virus, a member of the Poxviridae, expresses many proteins involved in immune evasion. In this review, we present a brief characterisation of the virus and its effects on host cells and discuss representative secreted and intracellular proteins expressed by vaccinia virus that are involved in modulation of innate immunity. These proteins target different aspects of the innate response by binding cytokines and interferons, inhibiting cytokine synthesis, opposing apoptosis or interfering with different signalling pathways, including those triggered by interferons and toll-like receptors.

Keywords

vaccinia virusimmune evasionsignal transductionnuclear factor kappa Btoll-like receptors
Type
Research Article
Information
Parasitology , Volume 130 , Issue S1 , March 2005 , pp. S11 - S25
Copyright
© 2005 Cambridge University Press

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