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Genetic heterogeneity in helminths — a reply

Published online by Cambridge University Press:  06 April 2009

R. M. Anderson ,
R. M. May  and
S. Gupta
R. M. Anderson
Affiliation:
Department of Zoology, University of Oxford, Oxford OX1 3PS
R. M. May
Affiliation:
Department of Zoology, University of Oxford, Oxford OX1 3PS
S. Gupta
Affiliation:
Department of Zoology, University of Oxford, Oxford OX1 3PS
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Extract

The previous paper in this issue Computer model of the maintenance and selection of genetic heterogeneity in polygamous helminths by Saul uses an individual-based computer simulation to explore aspects of the transmission and maintenance of genetic heterogeneity among polygamous intestinal helminths, both in the absence and in the presence of external selection pressures resulting from chemotherapy. Saul finds that, in the absence of any selective effects, genetic heterogeneity persists, contradicting the results presented by Anderson, May & Gupta (1989) that mating probability functions create density-dependent and frequency-dependent selective pressures against a rare allele, which eventually leads to its elimination.

Keywords

helminthgenetic heterogeneitychemotherapy
Type
Research Article
Information
Parasitology , Volume 111 , Issue 4 , November 1995 , pp. 537 - 538
Copyright
Copyright © Cambridge University Press 1995

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References

REFERENCES

Anderson, R. M., May, R. M. & Gupta, S. (1989). Non-linear phenomena in host–parasite interactions. Parasitology 99, S59–S79.CrossRefGoogle ScholarPubMed
Saul, A. (1995). Computer model of the maintenance and selection of genetic heterogeneity in polygamous helminths. Parasitology 111, 531–6.CrossRefGoogle ScholarPubMed
Tcheum, Tchuent L. A., Jourdane, J. & Southgate, V. R. (1994). Mating competition between Schistosoma mansoni and S. intercalation: Epidemiological implications. Abstract in The British Society for Parasitology, Spring Meeting.Google Scholar