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Immunological interactions between Trichinella spiralis and Trichuris muris in the intestine of the mouse

Published online by Cambridge University Press:  06 April 2009

R. G. Burce  and
D. Wakelin
R. G. Burce
Affiliation:
Depatment of Zoology and Wellcome laboratories for Exprimental Parasitology,`University of Glasgow, G12 8QQ
D. Wakelin
Affiliation:
Depatment of Zoology and Wellcome laboratories for Exprimental Parasitology,`University of Glasgow, G12 8QQ
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Extract

In outbred (CFLP) and inbred (NIH) mice, the inflammatory response which is thought to be party responsible for the expulsion of Trichinella spiralis from the mid-region of the small intestine, also seemed to be largely responsible fo rthe simulataneous (i.e. early) expulsion of Trichuris muris from the caecum and large intestine during concurrent primary infections. The intractive explusion operated only when the concurrent infections were timed to produce T. Spiralis expulsion before T. muris expulsion would normally occur and the effect persisted for several days after T. Spiralis has been expelled.

Interactive expulsion wasss depressed during application of the nonsteroid, anti-inflammatory drug indomethacin and by T-cell expulsion of T. spiralis. These results indicate that a T-cell mediated inflammatory response was probably the basis of the interaction.

When the timing of the infections was altered such that the expulsion of T. spiralis there was no reciprocal ecpulsion of the latter. Mice immunized againest one or the other species did not show cross-immunity on heterologus challenge, confirming that the interaction did not involve similar antigens in the two species. The interactive expulsive response is considered as an example of an indirect cross-immunity.

Type
Research Article
Information
Parasitology , Volume 74 , Issue 2 , April 1977 , pp. 163 - 173
Copyright
Copyright © Cambridge University Press 1977

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References

Bruce, R. G. (1970). Trichinella spiralis: fine structure of the body wall with special reference to the formation and moulting of cuticle. Exprimental Parasitology 28, 499–511.CrossRefGoogle Scholar
Bruce, R. G. (1974). Occurrence of hypodermal gland cells in the bacillary band of Trichinella spiralis during two phases of its lige cycle. In Trichinellosis (ed. Kim, C. W.), pp. 43–8. New York: Intext Educational Publishers.Google Scholar
Cox, H. W. (1952). Journal of the Elisha Mitchell Scientific Society 68, 222–35 cited by Larsh, J.E. (1963) in Exprimental Trichiniasis. Advances in Parasitology 1, 213–82.Google Scholar
Despommier, D. D. & Muller, M. (1970). The stichosome of Trichinella spiralis: its structure and function. Journal of Parasitology 56, Sect, II, part 1, 76.Google Scholar
Dineen, J. K. & Kelly, j. D. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats: the role of a cellular componenet derived from bone marrow. International Archives of Allergy and Applied Immunology 45, 759–66.CrossRefGoogle Scholar
Faubert, G. & Tanner, C. E. (1971). Trichinella spiralis: Inhibition of sheep haemaglutinins in mice. Exprimental Parasitology 30, 120–3.CrossRefGoogle ScholarPubMed
Holmes, J. C. (1961). Effects of concurrent infections on Hymenolepis diminuta (Gestoda) and Moniliformis dubius (Acanthocephala). I. General effects and comparision with crowding. Journal of Parasitology 47, 209–16.CrossRefGoogle Scholar
Larsh, J. E. & Race, G. J. (1975). Allergic inflammation as a hypothesis d\for the expulsion of worms from tissues–a review. Exprimental Parasitology 37, 251–66.CrossRefGoogle Scholar
larsh, J. E. & Weatherly, N. F. (1975). Cell-mediated immunity againest certain parasitic worms. Advances in Parasitology 13, 183–222.CrossRefGoogle Scholar
Larsh, J. E., Ottolenghi, A. & Weatherly, N. F. (1974). Trichinella spiralis: phospholipase in challenged mice and rats. Exprimental Parasitology 36, 299–306.CrossRefGoogle ScholarPubMed
Love, R. J., Ogilvie, B. M. & McLaren, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology 30, 7–16.Google ScholarPubMed
Lough, C. D. (1962). Increased resistance to Trichinella spiralis in the laboratory rat following with Nippostrongylus (brasiliensis) muris. Journal of Parasitology 48, 24–6.CrossRefGoogle Scholar
Mapes, C. J. & Coop, R. L. (1970). The interaction of infections of Heamonchus contortus and Nematodirus battus in lambs. 1. The effect of Heamonchus of subsequent infections of Nematodirus. Journal of Comparative pathology 80, 123–36.CrossRefGoogle Scholar
Murray, M. (1972). Immediate hypersensitivity effector mechanisms. II. In vivo reactions. In Immunity to Parasitic Animals (ed. Soulsby, E. J. L.), Pp. 155–90. New York and London: Academic Press.Google Scholar
Ogilvie, B. M. & Love, R. J. (1974). Co-operation between antibodies and cells immunity to a nematode parasite. Transplanation Reviews 19, 147–68.Google ScholarPubMed
Sheffield, H. G. (1963). Election microscopy of the bacillary band and stichosome of Trichuris muris and T. vulpis. Journal of Parasitology 49, 998–1009.CrossRefGoogle Scholar
Stewart, D. F. (1955). ‘Self-cure’ in nematode infections in sheep. Nature, London 176, 1273.CrossRefGoogle Scholar
Stahl, W. (1966). Exprimental aspiculuriasis. 2. Effects of concurrent helminth infection. Exprimental parasitology 18, 116–23.CrossRefGoogle Scholar
Svet-Moldavsky, G. J., Shaghijan, G. S., Chernyakhovskaya, I. Y., Mkheidze, D. M., Litovchenko, T. A., Ozeretskovskaya, N. N. & Kadaghidze, Z. G. (1970). Inhibition of skin allograft rejection in Trichinella infected mice. Transplanation 9, 69–70.CrossRefGoogle Scholar
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. parasitology 57, 515–24.CrossRefGoogle ScholarPubMed
Wakelin, D. (1974). The antigens of Trichiris muris which stimulate protective immunity in mice. Proceedings of IIIrd International Congress of Parsitology 3, 1172.Google Scholar
Wakelin, D. (1975). Immune expulsion of Trichuris muris from mice during a primary infection: analysis of the componments involved. Parasitology 70, 397–405.CrossRefGoogle Scholar
Wakelin, D. & Bruce, R. C. (1974). Heterologous immunity in mice infected with Trichinella spiralis. Proceedings of IIIrd International Congress of Parasitology 3, 1187Google Scholar
Wakelin, D. & Selby, G. R. (1974). Thymus-dependency of the immune response of muce to a primary infection with the nematode Trichuris muris. International Journal for Parasitology 4, 657–61.CrossRefGoogle Scholar
Walls, R. S., Carter, R. L., Leuchars, E. & Davies, A. J. S. (1973). The immunopathology of trichinosis in T-cell deficient mice. Clinical and Exprimental Immunology 13, 231–43.Google ScholarPubMed