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Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges

Published online by Cambridge University Press:  28 May 2014

ABEBE GENETU BAYIH  and
DYLAN R. PILLAI
ABEBE GENETU BAYIH
Affiliation:
Department of Microbiology, Immunology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, AB T2L 2K8, Canada Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Calgary, Calgary, AB T2L 2K8, Canada
DYLAN R. PILLAI*
Affiliation:
Department of Microbiology, Immunology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, AB T2L 2K8, Canada Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Calgary, Calgary, AB T2L 2K8, Canada
*
* Corresponding author: University of Calgary, Diagnostic & Scientific Centre, Room 1W-416, 9-3535 Research Road NW, Calgary, AB T2L 2K8, Canada. E-mail: dylanrpillai@gmail.com
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Summary

This review highlights studies conducted in murine models to evaluate the efficacy of compounds targeting Heat shock protein (Hsp) 90 of malaria. Both advances achieved and limitations that exist are highlighted.

Keywords

MalariaHsp90mouse studies
Type
Special Issue Article
Information
Parasitology , Volume 141 , Special Issue 9: Heat shock proteins as drug targets in infectious diseases , August 2014 , pp. 1216 - 1222
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Copyright
Copyright © Cambridge University Press 2014 

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