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Relocation of Schistosoma mansoni in the lungs and resistance to reinfection in Rattus rattus

Published online by Cambridge University Press:  06 April 2009

D. Imbert-Establet  and
C. Combes
D. Imbert-Establet
Affiliation:
URA CNRS 698, Centre de Biologie et d'ecologie Tropicale et Méditerranéenne, Université Avenue de Villeneuve, 66860 Perpignan Cedex, France
C. Combes
Affiliation:
URA CNRS 698, Centre de Biologie et d'ecologie Tropicale et Méditerranéenne, Université Avenue de Villeneuve, 66860 Perpignan Cedex, France
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Summary

The localization of adult Schistosoma mansoni originating from Guadeloupe (West Indies) was analysed in the natural host Rattus rattus in experimental and natural infections. A transfer of schistosomes from the porto-mesenteric system to the lungs occurs between the 4th and the 20th weeks post-infection, with a peak between 4 and 8 weeks; it should be noted that the worms start laying eggs at 4 weeks post-infection. In both experimentally and naturally infected R. rattus the relocation of schistosomes in the lungs is correlated with the total worm burden. Between 6 and 12 weeks post-infection some adult worms and numerous eggs are trapped in the liver. A high mortality in the worm population coincides with the migration of the parasites from the porto-mesenteric veins to the lungs. In re-infected R. rattus a relationship appears between the presence of schistosomes in the lungs and resistance to reinfection. It is concluded that, as already postulated previously in mice, resistance to re-infection in the natural host R. rattus is at least partly correlated with the hepatic pathology caused by the schistosomes of the primary infection.

Keywords

Schistosoma mansoniRattus rattusrelocationresistance
Type
Research Article
Information
Parasitology , Volume 104 , Issue 1 , February 1992 , pp. 51 - 57
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Coulson, P. S. & Wilson, R. A. (1989). Portal shunting and resistance to Schistosoma mansoni in 129 strain mice. Parasitology 99, 383–9.CrossRefGoogle ScholarPubMed
Cox, F. E. G. (1990). The mouse that wasn't immune. Nature, London 345, 18.CrossRefGoogle ScholarPubMed
Elsaghier, A. A. F., Knopf, P. M., Mitchell, G. F. & Mclaren, D. J. (1989). Schistosoma mansoni: evidence that ‘non-permissiveness’ in 129/Ola mice involves worm relocation and attrition in the lungs. Parasitology 99, 365–75.CrossRefGoogle ScholarPubMed
Elsaghier, A. A. F. & Mclaren, D. J. (1989). Schistosoma mansoni: evidence that vascular abnormalities correlate with the ‘non-permissive’ trait in 129/Ola mice. Parasitology 99, 377–81.CrossRefGoogle ScholarPubMed
Erickson, D. G. (1974). An efficient technique for exposure of rodents to Schistosoma haematobium. Journal of Parasitology 60, 553–4.CrossRefGoogle Scholar
Harrison, R. A., Bickle, Q. D. & Doenhoff, M. D. (1982). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. Evidence that the mechanisms which mediate resistance during early patent infections may lack immunological specificity. Parasitology 84, 93–110.CrossRefGoogle ScholarPubMed
Imbert-Establet, D. (1982). Infestation naturelle des rats sauvages par Schistosoma mansoni en Guadeloupe. Annales de Parasitologie humaine et comparée 57, 573–85.CrossRefGoogle ScholarPubMed
Jourdane, J. & Imbert-Establet, D. (1980). Etude expérimentale de la permissivité du rat sauvage (Rattus rattus) de Guadeloupe à l'égard de Schistosoma mansoni. Hypothèses sur le rôle de cet hôte dans la dynamique des foyers naturels. Acta Tropica 37, 41–51.Google Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1969). The immunology of schistosomiasis. Advances in Parasitology 7, 41–93.CrossRefGoogle ScholarPubMed
Theron, A., Pointier, J. P. & Combes, C. (1979). Approche écologique de la responsabilité de l'Homme et du Rat dans le fonctionnement d'un site de transmission de Schistosoma mansoni en Guadeloupe. Annales de Parasitologie humaine et comparée 53, 223–34.CrossRefGoogle Scholar
Wilson, R. A. (1980). Is immunity to Schistosoma mansoni in the chronically infected laboratory mouse an artefact of pathology? Proceedings of the Third European Multicolloquium of Parasitology, p 37.Google Scholar
Wilson, R. A. (1990). Leaky livers, portal shunting and immunity to schistosomes. Parasitology Today 6, 354–8.CrossRefGoogle ScholarPubMed
Wilson, R. A., Coulson, P. S. & Mchugh, S. M. (1983). A significant part of the ‘concomitant immunity’ of mice to Schistosoma mansoni is the consequence of a leaky hepatic portal system, not immune killing. Parasite Immunology 5, 595–601.CrossRefGoogle Scholar