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The ultrastructure of taeniid cestode oncospheres and localization of host-protective antigens

Published online by Cambridge University Press:  16 October 2009

A. JABBAR ,
Z. SWIDERSKI ,
D. MLOCICKI ,
I. BEVERIDGE  and
M. W. LIGHTOWLERS
A. JABBAR
Affiliation:
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
Z. SWIDERSKI
Affiliation:
Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda Street, 00-818 Warsaw, Poland Medical University of Warsaw, Department of General Biology and Parasitology, 5 Chalubinskiego Street, 02-004 Warsaw, Poland
D. MLOCICKI
Affiliation:
Witold Stefanski Institute of Parasitology, Polish Academy of Sciences, 51/55 Twarda Street, 00-818 Warsaw, Poland Medical University of Warsaw, Department of Medical Biology, 73, Nowogrodzka Street, 02-018 Warsaw, Poland
I. BEVERIDGE
Affiliation:
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
M. W. LIGHTOWLERS*
Affiliation:
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
*
*Corresponding author. Tel.: +61 3 9731 2284. Fax.: +61 3 9741 5461. E-mail: marshall@unimelb.edu.au
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Summary

Taeniid eggs contain an infective larval form of the parasite, known as the oncosphere, which has been found to be highly susceptible to attack by the host's immune system and this fact has been exploited in the development of highly effective vaccines. Relatively little is known about the structure of taeniid oncospheres and the localization of host-protective antigens within or on the oncosphere. Here, we briefly review the current state of knowledge of the structure of the oncosphere and present preliminary data on the localization of a host-protective antigen within the oncospheres of Taenia ovis. The precise localization of the antigens, in the context of a detailed knowledge of the ultrastructure of the parasite, may reveal the immune mechanisms by which the taeniid parasites are killed by vaccine-induced immune responses, which, in turn, may provide clues about how vaccines could be developed against other parasitic helminths.

Keywords

oncosphereultrastructurevaccine antigenimmuno-localizationTaeniaEchinococcusCestoda
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 3: Development and applications of cestode and trematode laboratory models , March 2010 , pp. 521 - 535
Copyright
Copyright © Cambridge University Press 2009

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