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Gloomy Prospects and Roller Coasters: Finding Coherence in Genome-Wide Association Studies

Published online by Cambridge University Press:  01 January 2022

Carl F. Craver ,
Mikhail Dozmorov ,
Mark Reimers  and
Kenneth S. Kendler
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Abstract

We address Turkheimer’s argument that genome-wide association studies of behaviors and psychiatric traits will fail to produce coherent explanations. We distinguish two major sources of potential incoherence (heterogeneity and complexity), showing how they independently threaten coherence and considering how they are being and might better be addressed with protein and other databases and network tools.

Type
Biological Sciences and Medicine
Information
Philosophy of Science , Volume 87 , Issue 5: PSA 2018 - Proceedings of the 2018 biennial meeting of the Philosophy of Science Association. Part II Symposia Papers , December 2020 , pp. 1084 - 1095
Copyright
Copyright © The Philosophy of Science Association

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Footnotes

†

Thanks to Niklas Andersson, Lindley Darden, Susan Fitzpatrick, Mark Povich, and two anonymous referees for comments and to Frederick Eberhardt especially for discussing s-t cuts. This project is funded in part by the John Templeton Foundation via a Genetics and Human Agency Award. This work is solely the responsibility of its authors and does not necessarily represent the official view of the funder.

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