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Correlation between plasma levels of prolactin and chlorpromazine in psychiatric patients1

Published online by Cambridge University Press:  09 July 2009

T. Kolakowska ,
D. H. Wiles ,
A. S. McNeilly  and
M. G. Gelder
T. Kolakowska
Affiliation:
Department of Psychiatry, University of Oxford, Department of Chemical Pathology, St. Bartholomew's Hospital, London
D. H. Wiles
Affiliation:
Department of Psychiatry, University of Oxford, Department of Chemical Pathology, St. Bartholomew's Hospital, London
A. S. McNeilly
Affiliation:
Department of Psychiatry, University of Oxford, Department of Chemical Pathology, St. Bartholomew's Hospital, London
M. G. Gelder*
Affiliation:
Department of Psychiatry, University of Oxford, Department of Chemical Pathology, St. Bartholomew's Hospital, London
*
2Address for correspondence: Professor M. G. Gelder, Department of Psychiatry, The Warneford Hospital, Oxford OX3 7JX.
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Synopsis

Plasma levels of chlorpromazine (CPZ) and prolactin were measured repeatedly in 14 psychiatric patients throughout CPZ treatment. Mean prolactin level was elevated in 11 subjects (all six women and five of eight men). Mean plasma prolactin correlated significantly with mean plasma CPZ but not with the dose of the drug. Only patients with mean plasma prolactin above 35 ng/ml developed Parkinsonian side-effects.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 5 , Issue 2 , May 1975 , pp. 214 - 216
Copyright
Copyright © Cambridge University Press 1975

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Footnotes

1

This work was supported by grants from the Medical Research Council and the Oxford Regional Hospital Board.

References

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