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Depressed patients with schizophrenic or paranoid symptoms

Published online by Cambridge University Press:  09 July 2009

I. F. Brockington ,
R. E. Kendell  and
S. Wainwright
I. F. Brockington*
Affiliation:
Institute of Psychiatry, London
R. E. Kendell
Affiliation:
Institute of Psychiatry, London
S. Wainwright
Affiliation:
Institute of Psychiatry, London
*
1Address for correspondence: Dr I. F. Brockington, Illinois State Psychiatric Institute, 1601 West Taylor Street, Chicago, Ill. 60612, USA.
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Synopsis

Family history, response to treatment and outcome are reported in a series of 76 patients presenting with both depression and schizophrenic or paranoid symptoms. About 10% of psychotic admissions to the Maudsley and Bethlem Royal Hospitals met a study definition of ‘schizodepressive’ illness. The patients were highly heterogeneous in history, clinical picture and outcome. Many followed a typical schizophrenic course, and others a typical course for affective disorders, but only 4 were given a final diagnosis of manic depressive disease. The best predictors of poor outcome were a mode of onset as an exacerbation of previous psychotic symptoms and the presence of schizophrenic symptoms at some time without depression. The best predictors of good outcome were Stephens' criteria of good prognosis schizophrenia and Kasanin's concept of ‘acute schizo-affective psychosis’. These findings are not easily reconciled with Kraepelin's two entities principle but suggest a continuum of outcome between schizophrenia and unipolar depressive psychosis.

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 4 , November 1980 , pp. 665 - 675
Copyright
Copyright © Cambridge University Press 1980

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References

REFERENCES

Brockington, I. F. & Leff, J. P. (1979). Schizoaffective psychosis: definitions and incidence. Psychological Medicine 9, 91–99.CrossRefGoogle ScholarPubMed
Brockington, I. F., Kendell, R. E., Kellett, J. M., Curry, S. H. & Wainwright, S. (1978 a). Trials of lithium, chlorpromazine and amitriptyline in schizoaffective patients. British Journal of Psychiatry 133, 162–168.CrossRefGoogle ScholarPubMed
Brockington, I. F., Kendell, R. E. & Leff, J. P. (1978 b). Definitions of schizophrenia: concordance and prediction of outcome. Psychological Medicine 8, 387–398.CrossRefGoogle ScholarPubMed
Brockington, I. F., Wainwright, S. & Kendell, R. E. (1980). Manic patients with schizophrenic or paranoid symptoms. Psychological Medicine 10, 73–83.CrossRefGoogle ScholarPubMed
Carpenter, W. T., Strauss, J. S. & Bartko, J. J. (1973). Flexible system for the diagnosis of schizophrenia: report from the WHO Pilot Study of Schizophrenia. Science 182, 1275–1278.CrossRefGoogle ScholarPubMed
Cooper, J. E. (1967). Diagnostic change in a longitudinal study of psychiatric patients. British Journal of Psychiatry 113, 129–142.CrossRefGoogle Scholar
Kantor, S. J. & Glassman, A. H. (1977) Delusional depressions: natural history and response to treatment. British Journal of Psychiatry 131, 351–360.CrossRefGoogle ScholarPubMed
Kasanin, J. (1933). The acute schizoaffective psychoses. American Journal of Psychiatry 13, 97–126.CrossRefGoogle Scholar
Langfeldt, G. (1960). Diagnosis and prognosis in schizophrenia. Proceedings of the Royal Society of Medicine 53, 1047–1052.CrossRefGoogle ScholarPubMed
McGlashan, T. H. & Carpenter, W. T. (1976). Postpsychotic depression in schizophrenia. Archives of General Psychiatry 33, 231–239.CrossRefGoogle ScholarPubMed
Nie, N. H., Hadlai Hull, C., Jenkins, J. G., Steinbrenner, K. & Brent, D. H. (1973). Statistical Package for the Social Sciences (second edn). McGraw Hill: New York.Google Scholar
Perris, C. (1974). A Study of Cycloid Psychoses. Acta psychiatrica scandinavica Supplement 253. Munksgaard: Copenhagan.Google Scholar
Post, F. (1971). Schizoaffective symptomatology in late life. British Journal of Psychiatry 118, 437–445.CrossRefGoogle ScholarPubMed
Schneider, K. (1959). Clinical Psychopathology (trans. Hamilton, M. W.), pp. 133–134. Grune and Stratton: London and New York.Google Scholar
Spitzer, R., Endicott, J. & Robins, E. (1975). Research Diagnostic Criteria. Instrument No. 58. New York State Psychiatric Institute: New York.Google Scholar
Stephens, J. H., Astrup, C. & Mangrum, J. C. (1966). Prognostic factors in recovered and deteriorating schizophrenics. American Journal of Psychiatry 122, 1116–1121.CrossRefGoogle ScholarPubMed
Vaillant, G. E. (1964). An historical review of the remitting schizophrenics. Journal of Nervous and Mental Disease 138, 48–56.CrossRefGoogle Scholar
Welner, A., Croughan, J. L. & Robins, E. (1974). The group of schizoaffective and related psychoses—critique, record, follow-up and family studies. Archives of General Psychiatry 31, 628–631.Google Scholar
Welner, A., Croughan, J., Fishman, R. & Robins, E. (1977). The group of schizoaffective and related psychoses: a follow-up study. Comprehensive Psychiatry 18, 413–422.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar