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Failure of lithium treatment in established tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

Angus V. P. Mackay ,
Graham P. Sheppard ,
Bimal K. Saha ,
Brenda Motley ,
Anthony L. Johnson  and
C. David Marsden
Angus V. P. Mackay*
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Graham P. Sheppard
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Bimal K. Saha
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Brenda Motley
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Anthony L. Johnson
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
C. David Marsden
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
*
1I Address for correspondence: Dr A. V. P. Mackay, MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Medical School, Hills Road, Cambridge CB2 2QD.
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Synopsis

Eleven patients with tardive dyskinesia were treated with lithium carbonate in a placebo-controlled double-blind crossover study. No significant effect of lithium on either tardive dyskinesia or blood prolactin concentrations was demonstrated, but 5 patients developed pseudo-Parkinsonian features.

Type
Brief Communication
Information
Psychological Medicine , Volume 10 , Issue 3 , August 1980 , pp. 583 - 587
Copyright
Copyright © Cambridge University Press 1980

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References

Crane, G. E. (1978). Tardive dyskinesia and related neurologic disorders. In Handbook of Psychopharmacology, Vol. 10 (ed. Iversen, L. L., Iversen, S. D. and Snyder, S. H.), pp. 165–196. Plenum Press: New York and London.CrossRefGoogle Scholar
Dalen, P. (1973). Lithium therapy in Huntington‘s chorea and tardive dyskinesia. Lancer i, 107–108.CrossRefGoogle Scholar
Ehrensing, R. H. (1974). Lithium and M.R.I.H. in tardive dyskinesia. Lancer ii, 1459–1460.CrossRefGoogle Scholar
Flemembaum, A. (1977). Lithium inhibition of norepinephrine and dopamine receptors. Biological Psychiatry 12, 563–572.Google Scholar
Gallager, D. W., Pert, A. & Bunney, W. E. (1978). Haloperidolinduced presynaptic dopamine supersensitivity is blocked by chronic lithium. Nature 273, 309–312.CrossRefGoogle ScholarPubMed
Gerlach, J., Thorsen, K. & Munkvad, I. (1975). Effect of lithium on neuroleptic-induced tardive dyskinesia compared with placebo in a double-blind cross-over trial. Pharmakopsychiatrie 8, 51–56.CrossRefGoogle Scholar
Honigfeld, G., Gillis, R. D. & Klett, C. J. (1966). NOSIE-30: a treatment-sensitive ward behaviour scale. Psychological Reports 19, 180–182.CrossRefGoogle Scholar
Johnson, D. A. W. (1973). The side-effects of fiuphenazine decanoate. British Journal of Psychiatry 123, 519–522.CrossRefGoogle ScholarPubMed
Kane, J., Rifkin, A., Quitkin, F. & Klein, D. F. (1978). Extra- pyramidal side effects with lithium treatment. American Journal of Psychiatry 135 (7), 851–853.Google Scholar
Kazamatsuri, H., Chien, C. P. & Cole, J. O. (1973). Long- term treatment of tardive dyskinesia with haloperidol and tetrabenazine. American Journal of Psychiatry 130, 479–482.Google ScholarPubMed
Klawans, H. L., Weiner, W. J. & Nausieda, P. A. (1977). The effect of lithium on animal models of tardive dyskinesia. Progress in Neuropsychopharmacology 1, 53–60.CrossRefGoogle ScholarPubMed
Loudon, J. B. & Waring, H. (1976). Toxic reactions to lithium and haloperidol. Lancet ii, 1088.CrossRefGoogle Scholar
Mackay, A. V. P. & Sheppard, G. P. (1979). Pharmacotherapeutic trials in tardive dyskinesia. British Journal of Psychiatry 135, 489–499.CrossRefGoogle ScholarPubMed
MRC Brain Metabolism Unit (1972). Modified amine hypothesis for aetiology of affective illness. Lancet ii, 573.Google Scholar
Overall, J. E. & Gorham, D. R. (1962). The Brief Psychiatric Rating Scale. Psychological Reports 10, 799–812.CrossRefGoogle Scholar
Pert, A., Rosenblatt, J. E., Sivitt, C., Pert, C. B. & Bunney, W. E. (1978). Long term treatment with lithium prevents the development of dopamine receptor supersensitivity. Science 201, 171–173.CrossRefGoogle ScholarPubMed
Prange, A., Wilson, I. C., Morris, C. E. & Hall, C. D. (1973). Preliminary experience with tryptophan and lithium in tardive dyskinesia. Psychopharmacology Bulletin 9, 36–37.Google Scholar
Quitkin, F., Rifkin, A., Gochfeld, L. & Klein, D. F. (1977). Tardive dyskinesia: are first signs reversible? American Journal of Psychiatry 134, 84–87.Google ScholarPubMed
Reda, F. A., Escoban, J. I. & Scanlan, J. M. (1975). Lithium carbonate inthe treatment of tardive dyskinesia. AmericanJournal of Psychiatry 132, 560–562.Google Scholar
Schou, M. (1976). Pharmacology and toxicology of lithium. Annual Review of Pharmacology 16, 231–243.CrossRefGoogle ScholarPubMed
Simpson, G. M. (1973). Tardive dyskinesia (letter to the Editor). British Journal of Psychiatry 122, 618.CrossRefGoogle Scholar
Simpson, G. M. & Angus, J. W. S. (1970). A rating scale for extrapyramidal side-effects. Ada psychiatrica scandinavica Supplement 212, 11–19.CrossRefGoogle ScholarPubMed
Simpson, G. M., Branchey, M. H., Lee, J. H., Voitashevsky, A. & Soubok, B. (1976). Lithium in tardive dyskinesia. Pharmakopsychiarrie 9, 76–80.CrossRefGoogle ScholarPubMed
Simpson, G. M., Lee, J. H., Soubok, B. & Gardos, G. (1979). A rating scale for tardive dyskinesia. Psychopharmacology 64, 171–179.CrossRefGoogle ScholarPubMed
Vocaflor, L. (1975). Lithium side-effects and toxicity: the clinical picture. In Lithium Research and Therapy (ed. Johnson, F. N.), pp. 211–225. Academic Press: London.Google Scholar