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The influence of specific chronic somatic conditions on the care for co-morbid depression in general practice

Published online by Cambridge University Press:  10 September 2007

J. Nuyen*
Affiliation:
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands
P. M. Spreeuwenberg
Affiliation:
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands
L. Van Dijk
Affiliation:
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands
G. A. M. Van den Bos
Affiliation:
Department of Social Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
P. P. Groenewegen
Affiliation:
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands
F. G. Schellevis
Affiliation:
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands Department of General Practice/EMGO Institute, VU University Medical Centre, VU University Amsterdam, The Netherlands
*
*Address for correspondence: J. Nuyen, M.Sc., NIVEL, Netherlands Institute for Health Services Research, Otterstraat 118-124, PO Box 1568, 3500 BN Utrecht, The Netherlands/Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Da Costakade 45, PO Box 725, 3500 AS Utrecht, The Netherlands. (Email: jnuijen@trimbos.nl)

Abstract

Background

Limited information exists on the relationship between specific chronic somatic conditions and care for co-morbid depression in primary care settings. Therefore, the present prospective, general practice-based study examined this relationship.

Method

Longitudinal data on morbidity, prescribing and referrals concerning 991 patients newly diagnosed with depression by their general practitioner (GP) were analysed. The influence of a broad range of 13 specific chronic somatic conditions on the initiation of any depression care, as well as the prescription of continuous antidepressant therapy for 180 days, was examined. Multilevel logistic regression analysis was used to control for history of depression, psychiatric co-morbidity, sociodemographics and interpractice variation.

Results

Multilevel analysis showed that patients with pre-existing ischaemic heart disease (72.1%) or cardiac arrhythmia (59.3%) were significantly less likely to have any depression care being initiated by their GP than patients without chronic somatic morbidity (88.0%). No other specific condition had a significant influence on GP initiation of any care for depression. Among the patients being prescribed antidepressant treatment by their GP, none of the conditions was significantly associated with being prescribed continuous treatment for 180 days.

Conclusions

Our study indicates that patients with ischaemic heart disease or cardiac arrhythmia have a lower likelihood of GP initiation of any care for depression after being newly diagnosed with depression by their GP. This finding points to the importance of developing interventions aimed at supporting GPs in the adequate management of co-morbid depression in heart disease patients to reduce the negative effects of this co-morbidity.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2007

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References

Anderson, IM, Nutt, DJ, Deakin, JF (2000). Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. British Association for Psychopharmacology. Journal of Psychopharmacology 14, 320.Google Scholar
APA (2000). Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. American Journal of Psychiatry 157 (Suppl. 4), 145.Google Scholar
Barth, J, Schumacher, M, Herrman-Lingen, C (2004). Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosomatic Medicine 66, 802813.Google Scholar
Berkman, LF, Blumenthal, J, Burg, M, Carney, RM, Catellier, D, Cowan, MJ, Czajkowski, SM, DeBusk, R, Hosking, J, Jaffe, A, Kaufmann, PG, Mitchell, P, Norman, J, Powell, LH, Raczynski, JM, Schneiderman, N (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. Journal of the American Medical Association 289, 31063116.Google Scholar
Bogner, HR, Ford, DE, Gallo, JJ (2006). The role of cardiovascular disease in the identification and management of depression by primary care physicians. American Journal of Geriatric Psychiatry 14, 7178.Google Scholar
Cole, SA, Christensen, JF, Raju, M, Feldman, M (1997). Depression. In Behavioral Medicine in Primary Care: A Practical Guide (ed. Feldman, M. D. and Christenson, J. F.), pp. 177192. Appleton and Lange: Stamford, CT.Google Scholar
Dunn, RL, Donoghue, JM, Ozminkowski, RJ, Stephenson, D, Hylan, TR (1999). Longitudinal patterns of antidepressant prescribing in primary care in the UK: comparison with treatment guidelines. Journal of Psychopharmacology 13, 136143.Google Scholar
Evans, DL, Charney, DS, Lewis, L, Golden, RN, Gorman, JM, Krishnan, KRR, Nemeroff, CB, Bremner, JD, Carney, RM, Coyne, JC, Delong, MR, Frasure-Smith, N, Glassman, AH, Gold, PW, Grant, I, Gwyther, L, Ironson, G, Johnson, RL, Kanner, AM, Katon, WJ, Kaufmann, PG, Keefe, FJ, Ketter, T, Laughren, TP, Leserman, J, Lyketsos, CG, McDonald, WM, McEwen, BS, Miller, AH, Musselman, D, O'Connor, C, Petitto, JM, Pollock, BG, Robinson, RG, Roose, SP, Rowland, J, Sheline, Y, Sheps, DS, Simon, G, Spiegel, D, Stunkard, A, Sunderland, T, Tibbits, JR, Valvo, WJ (2005). Mood disorders in the medically ill: scientific review and recommendations. Biological Psychiatry 58, 175189.CrossRefGoogle Scholar
Goldstein, H (1995). Multilevel Statistical Models. Wiley: New York.Google Scholar
Katon, W, Cantrell, CR, Sokol, MC, Chiao, E, Gdovin, JM (2005). Impact of antidepressant drug adherence on co-morbid medication use and resource utilization. Archives of Internal Medicine 165, 24972503.Google Scholar
Katon, WJ (2003). Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biological Psychiatry 54, 216226.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, P, Demler, O, Jin, R, Koretz, D, Merikangas, KR, Rush, AJ, Walters, EE, Wang, PS (2003). The epidemiology of major depressive disorder: results from the National Co-morbidity Survey Replication (NCS-R). Journal of the American Medical Association 289, 30953105.Google Scholar
Klinkman, MS (1997). Competing demands in psychosocial care. A model for the identification and treatment of depressive disorders in primary care. General Hospital Psychiatry 19, 98111.CrossRefGoogle Scholar
Krishnan, KR (2003). Co-morbidity and depression treatment. Biological Psychiatry 53, 701706.Google Scholar
Kurdyak, PA, Gnam, WH (2004). Medication management of depression: the impact of co-morbid chronic medical conditions. Journal of Psychosomatic Research 57, 565571.Google Scholar
Lamberts, H, Wood, W (1987). International Classification of Primary Care (ICPC). Oxford University Press: Oxford.Google Scholar
Metsemakers, JF, Hoppener, P, Knotterus, JA, Kocken, RJ, Limonard, CB (1992). Computerized health information in The Netherlands: a registration network of family practices. British Journal of General Practice 42, 102106.Google Scholar
LINH (Netherlands Information Network of General Practice) (2006). Netherlands Institute for Health Services Research (NIVEL), the Centre for Quality of Care Research (WOK), the National Association of General Practitioners (LHV), the Dutch College of General Practitioners (NHG). (www.linh.nl). Accessed 15 May 2006.Google Scholar
Nutting, PA, Rost, K, Smith, J, Werner, JJ, Elliot, C (2000). Competing demands from physical problems: effect on initiating and completing depression care over 6 months. Archives of Family Medicine 10, 10591064.CrossRefGoogle Scholar
Nuyen, J, Schellevis, FG, Satariano, WA, Spreeuwenberg, PM, Birkner, MD, Van den Bos, GAM, Groenewegen, PP (2006). Co-morbidity was associated with neurologic and psychiatric disease: a general practice-based controlled study. Journal of Clinical Epidemiology 59, 12741284.CrossRefGoogle ScholarPubMed
Nuyen, J, Volkers, AC, Verhaak, PF, Schellevis, FG, Groenewegen, PP, Van den Bos, GA (2005). Accuracy of diagnosing depression in primary care: the impact of chronic somatic and psychiatric co-morbidity. Psychological Medicine 35, 11851195.CrossRefGoogle ScholarPubMed
Oxman, TE, Sengupta, A (2002). Treatment of minor depression. American Journal of Geriatric Psychiatry 10, 256264.Google Scholar
Patten, SB, Beck, CA, Kassam, A, William, JV, Barbui, C, Metz, LM (2005). Long-term medical conditions and major depression: strength of association for specific conditions in the general population. Canadian Journal of Psychiatry 50, 195202.Google Scholar
Rees, K, Bennett, P, West, R, Davey, SG, Ebrahim, S (2004). Psychological interventions for coronary heart disease. Cochrane Database of Systematic Reviews, Issue no. 2, CD002902.Google Scholar
Roose, SP, Miyazaki, M (2005). Pharmacologic treatment of depression in patients with heart disease. Psychosomatic Medicine 67 (Suppl. 1), S54S57.Google Scholar
Sartorius, N, Ustun, TB, Lecrubier, Y, Wittchen, HU (1996). Depression co-morbid with anxiety: results from the WHO study on psychological disorders in primary health care. British Journal of Psychiatry 168 (Suppl. 30), 3843.CrossRefGoogle Scholar
Sauer, WH, Berlin, JA, Kimmel, SE (2001). Selective serotonin reuptake inhibitors and myocardial infarction. Circulation 104, 18941898.CrossRefGoogle ScholarPubMed
Simon, GE, Lin, EH, Katon, W, Saunders, K, VonKorff, M, Walker, E, Bush, T, Robinson, P (1995). Outcomes of ‘inadequate’ antidepressant treatment. Journal of General Internal Medicine 10, 663670.Google Scholar
Simon, GE, VonKorff, M, Lin, E (2005). Clinical and functional outcomes of depression treatment in patients with and without chronic medical illness. Psychological Medicine 35, 271279.Google Scholar
Stein, MB, Cox, BJ, Afifi, TO, Belik, S.-L, Sareen, J (2006). Does co-morbid depressive illness magnify the impact of chronic physical illness? A population-based perspective. Psychological Medicine 36, 587596.Google Scholar
Steiner, JF, Prochazka, AV (1997). The assessment of refill compliance using pharmacy records: methods, validity, and applications. Journal of Clinical Epidemiology 50, 105116.Google Scholar
Taylor, CB, Youngblood, ME, Catellier, D, Veith, RC, Carney, RM, Burg, MM, Kaufmann, PG, Shuster, J, Mellman, T, Blumenthal, JA, Krishnan, R, Jaffe, AS (2005). Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Archives of General Psychiatry 62, 792798.Google Scholar
Unutzer, J, Katon, W, Callahan, CM, Williams, JW Jr., Hunkeler EHarpole, L, Hoffing, M, Della Penna, RD, Noel, PH, Lin, EH, Tang, L & Oishi, S (2003). Depression treatment in a sample of 1,801 depressed older adults in primary care. Journal of the American Geriatrics Society 51, 505514.Google Scholar
Unutzer, J, Simon, G, Belin, TR, Datt, M, Katon, W, Patrick, D. (2000). Care for depression in HMO patients aged 65 and older. Journal of the American Geriatrics Society 48, 871878.Google Scholar
Van den Akker, M, Schuurman, A, Metsemakers, J, Buntinx, F (2004). Is depression related to subsequent diabetes mellitus? Acta Psychiatrica Scandinavica 110, 178183.Google Scholar
Van Marwijk, HWJ, Grundmeijer, HGLM, Bijl, D, Van Gelderen, MG, De Haan, M, Van Weel-Baumgarten, EM, Burgers, JS, Boukes, FS, Romeijnders, ACM (2003). The Dutch College of General Practitioners (NHG) Practice Guideline ‘Depression’, first revision [in Dutch]. Huisarts en Wetenschap 46, 614633.Google Scholar
Van Melle, JP, De Jonge, P, Spijkerman, TA, Tijssen, JG, Van Veldhuisen, DJ, Van den Brink, RH, Van den Berg, MP (2004). Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosomatic Medicine 66, 814822.Google Scholar
Westert, GP, Schellevis, FG, De Bakker, DH, Groenewegen, PP, Bensing, JM, Van der Zee, J (2005). Monitoring health inequalities through general practice: the Second Dutch National Survey of General Practice. European Journal of Public Health 15, 5965.CrossRefGoogle ScholarPubMed
WHO (2006). Collaborating Centre for Drug Statistics Methodology. Norwegian Institute of Public Health (www.whocc.no). Accessed 15 May 2006.Google Scholar
Whooley, MA, Simon, GE (2000). Managing depression in medical outpatients. New England Journal of Medicine 343, 19421950.CrossRefGoogle ScholarPubMed
WONCA Classification Committee (1983). International Classification of Health Problems in Primary Care (ICHPPC-2-Defined). Oxford University Press: Oxford.Google Scholar
Zhang, X, Norris, SL, Gregg, EW, Cheng, YJ, Beckles, G, Kahn, HS (2005). Depressive symptoms and mortality among persons with and without diabetes. American Journal of Epidemiology 161, 652660.Google Scholar