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Multiple measures of hemispheric dysfunction in schizophrenia and depression

Published online by Cambridge University Press:  09 July 2009

Sid J. Schneider
Sid J. Schneider*
Affiliation:
Franklin Delano Roosevelt Veterans Administration Medical Center, Montrose, New York, USA
*
1Address for correspondence: Dr Sid J. Schneider, Franklin Delano Roosevelt Veterans Administration Medical Center, Montrose, NY 10548, USA.
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Synopsis

Electrodermal, electroencephalographic and perceptual measures of lateral hemispheric function were obtained from groups of chronic schizophrenics, depressives and normals on 2 occasions, separated by 4 weeks. The measures of hemispheric function were derived from previous research. About half of the schizophrenics were medicated on both occasions; the other schizophrenics underwent drug ‘washout’ before the first session. Results revealed that the measures of laterality were not strongly intercorrelated. In the perceptual task, the schizophrenics and normals displayed different laterality effects. Unlike the normals, the schizophrenics' left hemisphere function appeared to be inferior to the right hemisphere function in the perceptual task. The laterality effects of the depressives and normals differed on two electrodermal measures: skin conductance level and skin conductance response amplitude. The depressives' electrodermal activity from the right hand was diminished as compared with the left hand; the normals did not show this effect. Medication decreased electrodermal activity in the schizophrenics, but had no significant effect on laterality. These results suggest that the various measures of laterality used singly in previous research in psychopathology may not all assess the same phenomenon.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 2 , May 1983 , pp. 287 - 297
Copyright
Copyright © Cambridge University Press 1983

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References

REFERENCES

Annett, M. (1970). A classification of hand preferences by association analysis. British Journal of Psychology 61, 303–321.CrossRefGoogle ScholarPubMed
Barchas, J. D., Patrick, R. L., Raese, J. & Berger, P. A. (1977). Neuropharmacological aspects of affective disorders. In Depression: Clinical, Biological and Psychological Perspectives (ed. Usdin, G.), pp. 139–165. Brunner Mazel: New York.Google Scholar
Beaumont, J. G. & Dimond, S. J. (1973). Brain disconnection and schizophrenia. British Journal of Psychology 123, 661–662.CrossRefGoogle ScholarPubMed
Buchsbaum, M. (1977). Psychophysiology and schizophrenia. Schizophrenia Bulletin 3, 7–14.CrossRefGoogle ScholarPubMed
Cheal, M. L. (1979). Stimulus-elicited investigation in apomorphinetreated gerbils. Behavioral and Neural Biology 27, 157–174.CrossRefGoogle ScholarPubMed
Cohen, G. (1972). Hemispheric differences in a letter classification task. Perception and Psychophysics 11, 139–142.CrossRefGoogle Scholar
Davison, K. & Bagley, C. R. (1969). Schizophrenia-like psychoses associated with organic disorders of the central nervous system: a review of the literature. In Current Problems in Neuropsychiatry (ed. Herrington, R. N.), pp. 113–184. Headley Brothers: Ashford, Kent.Google Scholar
Dimond, S. & Beaumont, J. G. (eds.) (1974). Hemisphere Function and the Human Brain. Wiley: New York.Google Scholar
Dykman, R. A., Reese, W. G., Galbrecht, C. R., Ackerman, P. T. & Sunderman, R. S. (1968). Autonomic responses in psychiatric patients. Annals of the New York Academy of Sciences 147, 237–303.CrossRefGoogle ScholarPubMed
Eaton, E. M., Buck, J., Maloney, M. P., Sloane, R. B., Whipple, K. & White, K. (1979). Hemispheric dysfunction in schizophrenia: assessment by visual perception tasks. Journal of Psychiatric Research 1, 325–332.CrossRefGoogle ScholarPubMed
Flor-Henry, P. (1976). Lateralized temporal–limbic dysfunction and psychopathology. Annals of the New York Academy of Sciences 280, 777–795.CrossRefGoogle ScholarPubMed
Flor-Henry, P. & Koles, Z. J. (1980). Studies in right/left hemispheric energy oscillations in schizophrenia, mania, depression and normals. Psychopharmacology Bulletin 16, 52–53.Google ScholarPubMed
Galin, D. (1974). Implications for psychiatry of left and right cerebral specialization. Archives of General Psychiatry 31, 572–583.CrossRefGoogle ScholarPubMed
Geschwind, N. (1978). Structural asymmetries of the human brain: significance for psychological functioning. Presented to the Eastern Psychological Association, Washington, D.C.Google Scholar
Glick, S. D., Jerussi, T. P. & Zimerberg, B. (1977). Behavioural and neuropharmacological correlates of nigro striatal asymmetry in rats. In Lateralisation in the Nervous System (ed. Harnard, S., Duty, K. W., Goldstein, L., Jaynes, J. and Krathemer, G.), pp. 213–249. Academic Press: London.CrossRefGoogle Scholar
Gruzelier, J. H. (1973). Bilateral asymmetry of skin conductance orienting activity and levels in schizophrenics. Biological Psychology 1, 21–42.CrossRefGoogle ScholarPubMed
Gruzelier, J. H. & Flor-Henry, P. (eds.) (1979). Hemispheric Asymmetries of Function in Psychopathology. Elsevier: Amsterdam.Google Scholar
Gruzelier, J. H. & Hammond, N. V. (1976). Schizophrenia: a dominant hemisphere temporal–limbic disorder? Research Communications in Psychology, Psychiatry and Behavior 1, 33–72.Google Scholar
Gruzelier, J. H. & Hammond, N. V. (1977). The effect of chlorpromazine upon bilateral asymmetries in bioelectncal skin reactivity of schizophrenics. Studia Psychologica 1, 40–50.Google Scholar
Gruzelier, J. H. & Hammond, N. V. (1978). The effect of chlorpromazine upon psychophysiological, endocrine and information processing measures in schizophrenia. Journal of Psychiatric Research 14, 167–182.CrossRefGoogle ScholarPubMed
Gruzelier, J. H. & Hammond, N. V. (1979). Gains, losses and lateral differences in the hearing of schizophrenic patients. British Journal of Psychology 70, 319–330.CrossRefGoogle ScholarPubMed
Gruzelier, J. H. & Venables, P. H. (1974). Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: replication and evidence of lateral asymmetry in patients with depression and disorders of personality. Biological Psychiatry 8, 55–73.Google ScholarPubMed
Gruzelier, J. H., Lykken, D. T. & Venables, P. H. (1972). Schizophrenia and arousal revisited: two-flash thresholds and electrodermal activity in activated and nonactivated conditions. Archives of General Psychiatry 26, 427–432.CrossRefGoogle ScholarPubMed
Gur, R. E. (1978). Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia. Journal of Abnormal Psychology 87, 226–238.CrossRefGoogle ScholarPubMed
Hammond, N. V. & Gruzelier, J. H. (1978). Laterality, attention and rate effects in the auditory temporal discrimination of chronic schizophrcnics: the effect of treatment with chlorpromazine. Quarterly Journal of Experimental Psychology 30, 91–103.CrossRefGoogle ScholarPubMed
Itil, T. M. (1977). Qualitative and quantitative EEG findings in schizophrenia. Schizophrenia Bulletin 3, 61–79.CrossRefGoogle ScholarPubMed
Kimura, D. (1966). Dual function asymmetry of the brain in visual perception. Neuropsychologia 4, 275–285.CrossRefGoogle Scholar
Kostandov, E. A. (1980). Asymmetry of visual perception and interhemispheric interaction. Neuroscience and Behavioral Physiology 10, 36–45.CrossRefGoogle ScholarPubMed
Lancet, (1979). Editorial: Psychosis and lateralization of the brain; ii, 1276–1277.Google Scholar
Luria, A. & Homskaya, E. (1970). Frontal lobe and the regulation of arousal processes. In Attention: Contemporary Theory and Research (ed. Mostofsky, D.), pp. 303–330. Appleton Century Crofts: New York.Google Scholar
MacKinnon, P. C. B. (1969). The palmar anhidrotic response to Stress in schizophrenic patients and in control groups. Journal of Psychiatric Research 7, 1–8.CrossRefGoogle ScholarPubMed
MacPherson, R. D., MacNeil, C. & Marble, A. E. (1976). Integrated circuit measurement of skin conductance. Behavioral Research Methods and Instrumentation 8, 361–364.CrossRefGoogle Scholar
Marshall, J. P. (1979). Somatosensory inattention after dopamine depleting intracerebral 6-OHDA injections: spontaneous recovery and pharmacological control. Brain Research 16, 311–324.CrossRefGoogle Scholar
McKeever, W. F. (1971). Lateral word recognition: effects of unilateral and bilateral presentation, asymmetry of bilateral presentation, and forced order of report. Quarterly Journal of Experimental Psychology 23, 410–416.CrossRefGoogle Scholar
Meltzer, H. Y. & Stahl, S. M. (1976). The dopamine hypothesis of schizophrenia: a review. Schizophrenia Bulletin 2, 19–76.CrossRefGoogle ScholarPubMed
Munro, D. M. (no date). Algorithm: fast Fourier transform. Unpublished manuscript: Engineering in Medicine Laboratory, Department of Electrical Engineering, Imperial College of Science and Technology, London.Google Scholar
Myslobodsky, M. S. & Horesh, N. (1978). Bilateral electrodermal activity in depressive patients. Biological Psychiatry 6, 111–120.CrossRefGoogle ScholarPubMed
Naeser, M. A., Levine, H. L., Benson, D. F., Stuss, D. T. & Weir, W. S. (1981). Frontal leukotomy size and hemispheric asymmetries on computerized tomographic scans of schizophrenics with variable recovery: Northampton Veterans Administration Study. Archives of Neurology 38, 30–37.CrossRefGoogle ScholarPubMed
Nieoullon, A., Cheramy, A. & Glowinski, J. (1977). Nigral and striatal dopamine release under sensory stimuli. Nature 269, 340–342.CrossRefGoogle ScholarPubMed
Oke, A., Keller, R., Massard, J. & Adams, R. (1978). Lateralisation of norepinephrine in the human thalamus. Science 200, 1411–1413.CrossRefGoogle ScholarPubMed
Roemer, R. A., Shagass, C., Straumanis, J. J. & Amadeo, M. (1978 a). Pattern evoked potential measurements suggesting lateralized hemispheric dysfunction in chronic schizophrenics. Biological Psychiatry 13, 185–202.Google ScholarPubMed
Roemer, R. A., Shagass, C., Straumanis, J. J. & Amadeo, M. (1978 b). Somatosensory and auditory evoked potential studies of functional differences between the cerebral hemispheres in psychosis. Biological Psychiatry 14, 357–373.Google Scholar
Saslow, M. (1967). Latency for saccadic eye movement. Journal of the Optical Society of America 57, 1030–1033.CrossRefGoogle ScholarPubMed
Serafetinides, E. A. (1972). Laterality and voltage in the EEG of psychiatric patients. Diseases of the Nervous System 33, 622–623.Google ScholarPubMed
Serafetinides, E. A. (1973). Voltage laterality in the EEG of psychiatric patients. Diseases of the Nervous System 34, 190–191.Google ScholarPubMed
Sourek, K. (1965). The Nervous Control of Skin Potentials in Man. Nakiadateistri Ceskoslovenska Akademie Ved: Prague.Google Scholar
Sperry, R. W. (1968). Hemisphere deconnection and unity in conscious awareness. American Psychologist 23, 723–733.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1975). Research and Diagnostic Criteria for a Selected Group of Functional Disorders. New York Psychiatric Institute: New York.Google Scholar
Taylor, M. A., Greenspan, B. & Abrams, R. (1979). Lateralized neuropsychological dysfunction in affective disorder and schizophrenia. American Journal of Psychiatry 136, 1031–1034.Google Scholar
Toone, B. K., Cooke, E. & Lader, M. H. (1979). The effect of temporal lobe surgery on electrodermal activity: implications for an organic hypothesis in the aetiology of schizophrenia. Psychological Medicine 9, 281–285.CrossRefGoogle ScholarPubMed
Venables, P. H. (1966). A comparison of two-flash and two-click thresholds in schizophrenic and normal subjects. Quarterly Journal of Experimental Psychology 18, 371–373.CrossRefGoogle ScholarPubMed
Venables, P. H. (1977). The electrodermal psychophysiology of schizophrenics and children at risk for schizophrenia: controversies and developments. Schizophrenia Bulletin 3, 28–49.CrossRefGoogle ScholarPubMed
Walker, E., Hoppes, E. & Emory, E. (1981). A reinterpretation of findings on hemispheric dysfunction in schizophrenia. Journal of Nervous and Mental Disease 169, 378–380.CrossRefGoogle ScholarPubMed
Wexler, B. E. (1980). Cerebral laterality and psychiatry: a review of the literature. American Journal of Psychiatry 137, 279–291.Google ScholarPubMed