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Obsessive–compulsive disorder and separation anxiety co-morbidity in early onset panic disorder

Published online by Cambridge University Press:  01 October 2001

R. GOODWIN ,
J. D. LIPSITZ ,
T. F. CHAPMAN ,
S. MANNUZZA  and
A. J. FYER
R. GOODWIN
Affiliation:
From the Anxiety Genetics Unit, Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY, USA
J. D. LIPSITZ
Affiliation:
From the Anxiety Genetics Unit, Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY, USA
T. F. CHAPMAN
Affiliation:
From the Anxiety Genetics Unit, Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY, USA
S. MANNUZZA
Affiliation:
From the Anxiety Genetics Unit, Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY, USA
A. J. FYER
Affiliation:
From the Anxiety Genetics Unit, Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York, NY, USA
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Abstract

Background. This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.

Methods. Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive–compulsive disorder, obsessive–compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.

Results. Earlier onset of panic disorder was found in patients with co-morbid obsessive–compulsive disorder, obsessive–compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive–compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive–compulsive disorder.

Conclusions. The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive–compulsive disorder and childhood separation anxiety disorder.

Type
Brief Communication
Information
Psychological Medicine , Volume 31 , Issue 7 , October 2001 , pp. 1307 - 1310
Copyright
© 2001 Cambridge University Press

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