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Failure of lithium treatment in established tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

Angus V. P. Mackay ,
Graham P. Sheppard ,
Bimal K. Saha ,
Brenda Motley ,
Anthony L. Johnson  and
C. David Marsden
Angus V. P. Mackay*
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Graham P. Sheppard
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Bimal K. Saha
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Brenda Motley
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
Anthony L. Johnson
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
C. David Marsden
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge; Warley Hospital, Essex; MRC Statistical Research and Services Unit, London; Institute of Psychiatry, London.
*
1I Address for correspondence: Dr A. V. P. Mackay, MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Medical School, Hills Road, Cambridge CB2 2QD.
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Synopsis

Eleven patients with tardive dyskinesia were treated with lithium carbonate in a placebo-controlled double-blind crossover study. No significant effect of lithium on either tardive dyskinesia or blood prolactin concentrations was demonstrated, but 5 patients developed pseudo-Parkinsonian features.

Type
Brief Communication
Information
Psychological Medicine , Volume 10 , Issue 3 , August 1980 , pp. 583 - 587
Copyright
Copyright © Cambridge University Press 1980

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