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Mood disorders in long-term survivors of stroke: associations with brain lesion location and volume

Published online by Cambridge University Press:  09 July 2009

M. Sharpe ,
K. Hawton ,
A. House ,
A. Molyneux ,
P. Sandercock ,
J. Bamford  and
C. Warlow
M. Sharpe*
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
K. Hawton
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
A. House
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
A. Molyneux
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
P. Sandercock
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
J. Bamford
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
C. Warlow
Affiliation:
University Departments of Psychiatry and Neurology, Oxford
*
1Address for correspondence: Dr M. Sharpe, University Department of Psychiatry, Warneford Hospital, Oxford 0X3 7JX.
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Synopsis

Sixty surviving patients from a community-based stroke register who had CT scan evidence of a single brain lesion and neurological signs appropriate to it were interviewed three to five years following their first-ever stroke. Mood disorder (anxiety and depression), physical disability, and intellectual impairment were assessed using standardized measures. The position and volume of the brain lesion was determined from CT scans performed soon after the stroke. The prevalence of depressive disorder was lower in this sample than that reported in previous studies (DSM-IIIR major depression 8 3 %; all DSM-IIIR depressive disorders 183%). Reports by other workers for an association of depressive disorder either with left-sided brain lesions, or with anteriorly placed lesions in the left cerebral hemisphere, were not supported. Neither was there evidence of a correlation between symptom score and proximity of the lesion to the anterior pole of the left cerebral hemisphere. Psychiatric symptom scores were however greater with larger volume brain lesions. Anxiety disorders, especially agoraphobia, were relatively common (20 % if diagnosed in the presence of depressive disorder), but were not related to lesion location or volume.

Type
Orginal Articles
Information
Psychological Medicine , Volume 20 , Issue 4 , November 1990 , pp. 815 - 828
Copyright
Copyright © Cambridge University Press 1990

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