Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-28T03:06:38.779Z Has data issue: false hasContentIssue false
  • English
  • Français

Variable clinical response to choline in tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

Henry A. Nasrallah ,
Frederick J. Dunner ,
Robert E. Smith ,
Mona McCalley-Whitters  and
Arnold D. Sherman
Henry A. Nasrallah*
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Frederick J. Dunner
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Robert E. Smith
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Mona McCalley-Whitters
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Arnold D. Sherman
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
*
1Address for correspondence: Dr Henry A. Nasrallah, Psychiatry Service (116A), Veterans Administration Medical Center, Iowa City, Iowa 52240, USA.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Tardive dyskinesia is widely believed to be a state of relative hyperdopaminergic and hypocholinergic imbalance in the striatum of patients chronically treated with neuroleptics. However, not all patients with tardive dyskinesia respond to cholinergic drugs, which theoretically should restore the balance and improve the symptoms. We report a controlled, double-blind, crossover study of choline chloride in 11 patients with persistent tardive dyskinesia. Seven patients showed partial or minimal improvement, while two did not change and two deteriorated. The results are discussed in the light of other similar findings in the literature, and the implications for pharmacological subtypes of tardive dyskinesia using cholinergic probes are explored.

Type
Brief Communication
Information
Psychological Medicine , Volume 14 , Issue 3 , August 1984 , pp. 697 - 700
Copyright
Copyright © Cambridge University Press 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Casey, D. & Denny, D. (1977). Pharmacological characterization of tardive dyskinesia. Psychopharmacology 54, 1–8.CrossRefGoogle ScholarPubMed
Davis, K. & Berger, P. (1978). Pharmacological investigations of the cholinergic imbalance hypotheses of movement disorders and psychosis. Biological Psychiatry 13, 23–49.Google ScholarPubMed
Davis, K., Berger, P. & Hollister, L. (1975). Choline for tardive dyskinesia. New England Journal of Medicine 293, 152.Google ScholarPubMed
Fann, W. & Lake, C. K. (1974). Cholinergic suppression of tardive dyskinesia. Psychopharmacologia 37, 101–107.CrossRefGoogle ScholarPubMed
Gerlach, J., Reisby, N. & Randrup, A. (1974). Dopaminergic hyper-sensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia. Psychopharmacologia 34, 21–35.CrossRefGoogle Scholar
Growdon, J., Hirsch, M. & Wurtman, R. (1977). Oral choline administration to patients with tardive dyskinesia. New England Journal of Medicine 297, 524–527.CrossRefGoogle ScholarPubMed
Jeste, D. V. & Wyatt, R. J. (1982). Therapeutic strategies against tardive dyskinesia: two decades of experience. Archives of General Psychiatry 39, 803–816.CrossRefGoogle ScholarPubMed
Kilbinger, H. (1973). Gas chromatographic estimation of acetylcholine in the rabbit heart using a nitrogen selective detector. Journal of Neurochemistry 21, 421–429.CrossRefGoogle ScholarPubMed
Moore, D. C. & Bowers, M. B. (1980). Identification of a subgroup of tardive dyskinesia patients by pharmacologie probes. American Journal of Psychiatry 137, 1202–1205.Google Scholar
Nasrallah, H. A. (1979). Methodological issues in tardive dyskinesia research. Schizophrenia Bulletin 5, 1–3.CrossRefGoogle ScholarPubMed
National Institute of Mental Health (1974). Abnormal Involuntary Movement Scale. Public Health Service: Bethesda, MD.Google Scholar
Schooler, N. R. & Kane, J. M. (1982). Research diagnoses for tardive dyskinesia. Archives of General Psychiatry 39, 486–487.Google ScholarPubMed
Tamminga, C.Smith, R. & Ericksen, S. (1977). Cholinergic influences in tardive dyskinesia. American Journal of Psychiatry 134, 769–774.Google ScholarPubMed
Tarsy, D. & Baldessarini, R. (1976). The tardive dyskinesia syndrome. In Clinical Neuropharmacology, Vol. 1 (ed. Klawans, H. L.), pp. 29–61. Raven Press: New York.Google Scholar
Tarsy, D., Leopold, N. & Sax, D. (1974). Physostigmine in choreiform movement disorder. Neurology 24, 28–33.CrossRefGoogle Scholar