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Plasma vitamin C: what does it measure?

Published online by Cambridge University Press:  02 January 2007

AR Ness ,
KT Khaw ,
S Bingham  and
NE Day
AR Ness*
Affiliation:
Senior Lecturer in Epidemiology, University of Bristol, Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
KT Khaw
Affiliation:
Professor of Clinical Gerontology, Department of Clinical GerontologyAddenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK
S Bingham
Affiliation:
Senior Scientist, MRC Dunn Clinical Nutrition Centre, Hills Road, Cambridge, CB2 2DH, UK
NE Day
Affiliation:
Professor of Public Health, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
*
*Corresponding author: Email Andy.Ness@bris.ac.uk
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Abstract

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Objective:

To examine the association between self-reported consumption of foods and plasma vitamin C levels.

Design:

A cross-sectional analysis of dietary data and plasma vitamin C levels. Subjects placed the following foods into frequency categories: fresh fruit, leafy greens, other vegetables, fatty fish, other fish, chicken, meat, meat products, eggs, cheese and brown bread. The six frequency categories ranged from ‘never’ to ‘at least daily’. Plasma vitamin C was measured by fluorometric assay.

Setting:

A population-based cohort study in Norfolk, UK.

Subjects:

598 men and 566 women aged 45–74 years not taking vitamin supplements.

Results:

Plasma vitamin C was positively correlated with intake of fresh fruit (r = 0.29 in men and r = 0.25 in women, P < 0.001), leafy greens (r = 0.20 in men P < 0.001, r = 0.13 in women P < 0.01), other vegetables (r = 0.20 in men P < 0.001, r = 0.14 in women P < 0.01) and brown bread (r = 0.28 in men, r = 0.17 in women, P < 0.001) and negatively associated with intake of meat products (r = −0.13 in men P = 0.02, r = −0.10 in women P < 0.01). The difference in plasma vitamin C between never and daily eaters of brown bread was 13.6 μmol l−1 in men and 9.9 μmol l−1 in women, P < 0.001

Conclusions:

These data suggest that plasma vitamin C is not only a marker of foods rich in vitamin C but of certain patterns of food consumption. Such patterns are likely to be population specific and might explain inconsistencies in biomarker–disease associations.

Keywords

Plasma vitamin CFoodsBiomarkers
Type
Research Article
Information
Public Health Nutrition , Volume 2 , Issue 1 , January 1999 , pp. 51 - 54
Copyright
Copyright © CABI Publishing 1999

References

1Pearce, N, de Sanjose, S, Boffetta, P, Kogevinas, M, Saracci, R, Savitz, D. Limitations of biomarkers of exposure in cancer epidemiology. Epidemiology 1995; 6: 190–4.CrossRefGoogle ScholarPubMed
2Bates, CJThurnham, DI. Biochemical markers of nutrient intake. In: Margetts, BM, Nelson, M, eds. Design Concepts in Nutritional Epidemiology. Oxford: Oxford University Press, 1991: 192–265.Google Scholar
3Gregory, J, Foster, K, Tyler, H, Wiseman, M. The Dietary and Nutritional Survey of British Adults. London: HMSO, 1990.Google Scholar
4Riboli, E. Nutrition and cancer: background and rationale of the European prospective Investigation into Cancer and Nutrition (EPIC). Ann. Oncol. 1992; 3: 783–91.CrossRefGoogle ScholarPubMed
5Key, TJA, Oakes, S, Davey, G, Moore, J, Edmond, LM, McLoone, UJ, Thurnham, DI. Stability of vitamins A, C, E, carotenoids, lipids, and testosterone in whole blood stored at 4C for 6 and 24 hours before separation of serum and plasma. Cancer Epidemiol. Biomarkers Prevention 1996; 5: 811–14.Google Scholar
6Vuilleumier, JP, Keck, E. Fluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. J. Micronutr. Analys. 1989; 5: 25–34.Google Scholar
7SPSS Inc. SPSS for Windows, release 6.0. Chicago, USA: 1993.Google Scholar
8Bolland, B, Welch, AA, Unwin, ID, Buss, DH, Paul, AA, Southgate, DAT. McCance and Widdowson's The Composition of Foods, fifth edition. London: Royal Society of Chemistry, 1991.Google Scholar
9Jacob, RA, Otradovec, CL, Russell, RM et al. Vitamin C status and nutrient interactions in a healthy elderly population. Am. J. Clin. Nutr. 1988; 48: 1436–42.CrossRefGoogle Scholar
10Heseker, H, Schneider, R. Requirement and supply of vitamin C, E and β-carotene for elderly men and women. Eur. J. Clin. Nutr. 1994; 48: 118–27.Google ScholarPubMed
11Bingham, SE, Gill, C, Welch, A, et al. Validation of dietary assessment in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. Int. J. Epidemiol. 1997; 26 (suppl. 1): S137–S151.CrossRefGoogle ScholarPubMed