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Magnetic resonance studies of the pathophysiology of murine malaria

Published online by Cambridge University Press:  17 March 2009

Roxanne Deslauriers ,
Yves Geoffrion ,
Keith W. Butler  and
Ian C. P. Smith
Roxanne Deslauriers
Affiliation:
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, CanadaK1A OR6
Yves Geoffrion
Affiliation:
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, CanadaK1A OR6
Keith W. Butler
Affiliation:
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, CanadaK1A OR6
Ian C. P. Smith
Affiliation:
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, CanadaK1A OR6
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Extract

The non-invasive and non-destructive aspects of NMR and ESR spectroscopy have prompted a variety of research on the pathophysiological impact of murine malaria. NMR is unique in its ability to monitor intracellular pH non-invasively in a heterogeneous sample, a compartmentalized cell and in a whole organism. It has also been shown to be sensitive to unusual structures and metabolic products in free-living protozoa such as Acanthamoeba (Deslauriers et al. 1982a) and Tetrahymena (Deslauriers et al. 1982b; Jarrell et al. 1981). Using the appropriate spin probe, ESR can give valuable information on membrane structure (Schreier, Polnaszek & Smith; 1978). It is particularly useful when quantities of material are limited.

Type
Research Article
Information
Quarterly Reviews of Biophysics , Volume 18 , Issue 1 , February 1985 , pp. 65 - 110
Copyright
Copyright © Cambridge University Press 1985

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