Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-10T17:02:19.217Z Has data issue: false hasContentIssue false
  • English
  • Français

Chromosome aberrations in workers of beach sand mineralindustries

Published online by Cambridge University Press:  23 September 2013

C. Meenakshi  and
Mary N. Mohankumar
Get access

Abstract

Beach Sand Mining (BSM) is a profitable industry earning a sizable income for the countryby way of foreign exchange. The Indian coast is rich in rare earths such as ilmenite,rutile, leucoxene, zircon, garnet and sillimanite, and is invariably associated withradioactive monazite. Due to the nature of the separation processes involved and themanual handling, workers in these factories are continuously being exposed to suspendedparticles containing naturally occurring radioactive materials. An attempt was made toestimate DNA damage using a chromosome aberration assay to monitor radiation effects inworkers of BSM industries in India. The study group comprised 27 BSM workers and 20controls. Percentage yields of dicentrics, acentric fragments and chromatid breaksobserved in the control group were 0.058 ± 0.017, 0.073 ± 0.03 and 0.22 ± 0.112,respectively. Percentage yields of dicentrics + centric rings, acentric fragments andchromatid breaks observed in the BSM group were 0.029 ± 0.01 (P value 0.19), 0.24 ± 0.06(P value 0.006) and 0.455 ± 0.06 (P value 0.0004), respectively. Elevated levels offragments and chromatid aberrations are suggestive of low-dose radiation effects and alsochemically-induced DNA damage.

Keywords

chromosome aberrationbeach sand miningradiation workerradon
Type
Research Article
Information
Radioprotection , Volume 48 , Issue 4 , October 2013 , pp. 563 - 573
Copyright
© EDP Sciences, 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aghamohammadi, S.Z., Goodhead, D.T., Savage, J.K. (1998) Induction of sister chromatid exchanges (SCE) in Go lymphocytes by plutonium-238 alpha-particles, Int. J. Radiat. Biol. 53, 909-915.Google Scholar
Al-sabti, K., Lloyd, D.C., Edwards, A.A., Stegnar, P. (1992) A survey of lymphocyte chromosomal damage in Slovenian workers exposed to occupational clastogens, Mutat. Res. 280, 215-23.Google Scholar
Anwar, W.A. (1997) Biomarkers of human exposure to pesticides, Environ. Health Perspect. 105, 801-806.Google Scholar
Babu, N., Vasumathi, N., BhimaRao, R. (2009) Recovery of Ilmenite and other Heavy minerals from Teri sands (Red sands) of Tamilnadu, India, J. Miner. Mater. Charact. Eng. 8, 149-159.
Balakrishnan, S., Rao, S.B. (1999) Cytogenetic analysis of peripheral blood lymphocytes of occupational workers exposed to low levels of ionizing radiation, Mutat. Res. 442, 37-42.Google Scholar
Ballardin, M., Antonelli, A., Cipollini, M., Fallahi, P., Scarpato, R., Tomei, A., Traino, C., Barale, R. (2007) Induction of chromatid-type aberrations in peripheral lymphocytes of hospital workers exposed to very low doses of radiation, Mutat. Res. 626, 61-68.Google Scholar
Bauchinger, M., Schmid, E., Einbrodt, H.J., Dresp, J. (1976) Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium, Mutat. Res. 40, 57-62.Google Scholar
Bilban, M., Jakopin, C.B. (2005) Incidence of cytogenetic damage in lead-Zinc mine workers exposed to radon, Mutagenesis 20, 187-191.Google Scholar
Brenner, D.J., Sachs, R.K. (1994) Chromosomal ‘Fingerprints’ of prior exposure to densely ionizing radiation, Radiat. Res. 140, 134-142.Google ScholarPubMed
Celik, M., Donbak, L., Unal, F., Yuzbasioglu, D., Aksoy, H., Yilmaz, S. (2007) Cytogenetic damage in workers from coal-fired power plant, Mutat. Res. 627, 158-163.Google ScholarPubMed
Deknudt, G., Léonard, A., Ivanov, B. (1973) Chromosome aberrations observed in male workers occupationally exposed to lead, Environ. Physiol. Biochem. 3, 132-138.Google Scholar
Dias, L.F., Antunes, L.M.G., Rezende, P.A., Carvalho, F.E., Silva, C.E., Matheus, M.J., Oliveira, J.V., Lopes, G.P., Pereira, A.G., Balarin, M.A. (2007) Cytogenetic analysis in lymphocytes from workers occupationally exposed to low levels of ionizing radiation, Environ. Toxicol. Pharmacol. 23, 228-233.Google ScholarPubMed
Donbak, L., Rencuzogullari, E., Yavuz, A., Topaktas, M. (2005) The genotoxic risk of underground coal miners from Turkey, Mutat. Res. 588, 82-87.Google Scholar
Elmagd, M.A., Daif, M.M., Eissa, H.M. (2008) Cytogenetic effects of radon inhalation, Radiat. Meas. 43, 1265-1269.Google Scholar
Haridasan, P.P., Pillai, P.M., Khan, H., Puranik, D. (2006) Natural radionuclides in zircon and related radiological impacts in mineral separation plants, Radiat. Prot. Dosim. 121, 364-369.Google Scholar
IAEA (2001) Cytogenetic Analysis for Radiation Dose Assessment, Technical Report Series No. 405, Vienna.
Johnson, F.M. (1998) The genetic effects of environmental lead, Mutat. Res. 410, 123-140.Google Scholar
Kandar, M.Z., Bahari, I.B. (1995) Radiation-induced chromosomal aberrations among TENORM workers: amang and Ilmenite processing workers of Malaysia, Mutat. Res. 351, 157-161.Google Scholar
Keshava, N., Ong, T.M. (1999) Occupational exposure to genotoxic agents, Mutat. Res. 437, 175-194.Google ScholarPubMed
Kopjar, N., Garaj-Vrhovac, V. (2005) Assessment of DNA damage in nuclear medicine personnel- comparative study with the alkaline comet assay and the chromosome aberration test, Int. J. Hyg. Environ. Health 208, 179-191.Google ScholarPubMed
Lazutka, J.R., Lekevièius, R., Dedonyte, V., Maciulevièiûte-Gervers, L., Mierauskiene, J., Rudaitiene, S., Slapsyte, G. (1999) Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: Effects of occupational and environmental exposures, Mutat. Res. 445, 225-239.Google Scholar
Leonard, A., Deknudt, G., Leonard, E.D., Decat, G. (1984) Chromosome aberrations in employees from fossil-fueled and nuclear-power plants, Mutat. Res. 138, 205-212.Google Scholar
Lloyd, D.C., Lucas, J.N., Edwards, A.A., Deng, W., Valente, E., Hone, P.A., Moquet, J.E. (2001) A study to verify a reported excess of chromosomal aberrations in blood lymphocytes of Nambian uranium miners, Radiat. Res. 155, 809-817.Google Scholar
Maffei, F., Angelini, S., Forti, C.G., Violante, S.N., Lodi, V., Mattioli, S. (2004) Spectrum of chromosomal aberrations in peripheral lymphocytes of hospital workers occupationally exposed to low doses of ionizing radiation, Mutat. Res. 547, 91-99.Google Scholar
Maki-Paakanen, J., Sorsa, M., Vainio, H. (1981) Chromosome aberrations and sister chromatid exchanges in lead-exposed workers, Hereditas 94, 269-275.Google Scholar
Martin, F., Earl, R., Tawn, E.J. (1991) A Cytogenetic study of men occupationally exposed to uranium, Br. J. Ind. Med. 48, 98-102.Google ScholarPubMed
Meenakshi, C., Mohankumar, M.N. (2012) Radon induced chromosome damage in blood lymphocytes of smokers, Res. J. Environ. Toxicology 6, 51-58.Google Scholar
Nordenson, I., Nordstrom, S., Sweins, A., Beckman, L. (1982) Chromosomal aberrations in lead- exposed workers, Hereditas 96, 265-268.Google ScholarPubMed
Padmala Reddy, C.H., Ramana Devi, V., Vidyullatha, V., Hema Prasad, M., Reddy, P.P., (2000) Chromosomal aberrations in smokers exposed to metallic dust in mint factory, Rev. Biomed. 11, 87-90.
Prabhavathi, A., Fatima, K.S., Srinivasa Rao, M., Reddy, P.P. (2000) Analysis of chromosomal aberration frequencies in the peripheral blood lymphocytes of smokers exposed to uranyl compounds, Mutat. Res. 466, 37- 41.Google ScholarPubMed
Pressl, S., Edwards, A., Stephan, G. (1999) The influence of age, sex and smoking habits on the background level of fish-detected translocations, Mutat. Res. 442, 89-95.Google Scholar
Ramalho, A.T., Nascimento, A.C. (1991) The fate of chromosomal aberrations in 137 Cs- exposed individuals in the Goiania radiation accident, Health Phys. 60, 67-70.Google Scholar
Ramsey, J.M, Moore, D.H. 2nd., Briner, F.J., Lee, D.A., Olsen, L.A., Senft, J.R., Tucker, J.D. (1995) The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting, Mutat. Res. 338, 95-106.Google Scholar
Rojas, E., Herrera, L.A., Poirier, L.A., Ostrosky-Wegman, P. (1999) Are metals dietary carcinogens? Mutat. Res. 443, 157-181. Google ScholarPubMed
Santa Maria, S.R., Arana, M., Ramirez, O. (2007) Chromosomal aberrations in peripheral lymphocytes from male native miners working in the peruvian Andes, Genet. Mol. Biol. 30, 1135-1138.Google Scholar
Scheepers, P.T. et al.(2002) Biomarkers for occupational diesel exhaust exposure monitoring (biomodem) – A study in underground mining, Toxicol. Lett. 134, 305-317.Google ScholarPubMed
Sinues, B., Izquierdo, M., Perez, V. (1990) Chromosome aberrations and urinary thioesters in smokers, Mutat. Res. 240, 289-293.Google Scholar
Smerhovsky, Z., Landa, K., Rossner, P., Juzova, D., Brabec, M., Zudova, Z., Hola, N., Zarska, H., Nevsimalova, E. (2002) Increased risk of cancer in radon-exposed miners with elevated frequency of chromosomal aberrations, Mutat. Res. 514, 165-176.Google ScholarPubMed
Suresh, K., Ajoy, K.C., Dhanasekaran, A., Balasundar, S., Santhanam, R., Gajendiran, V., Meenakshisundaram, V. (2003) Investigation of Radiation Levels in Beach Sand Mineral Industries – A preliminary Study, Radiat. Prot. Environ. 26, 1-2.Google Scholar
Tanaka, K., Kohda, A., Toyokawa, T., Ichinohe, K., Oghiso, Y. (2008) Chromosome aberration frequencies and chromosome instability in mice after long-term exposure to low-dose-rate gamma-irradiation, Mutat. Res. 657, 19-25.Google ScholarPubMed
Tanaka, K., Kamada, N. (2009) Distribution of breakpoints on chromatid-type aberration induced by three different radiations, in relation to fragile sites, Indian J. Sci. Technol. 2, 1-9.Google Scholar
Topaktas, M., Rencüzodullari, E., lla, H.B., Kayraldiz, A. (2002) Chromosome aberration and sister chromatid exchange in workers of the iron and steel factory of iskenderun Turkey, Teratog. Carcinog. Mutagen. 22, 411-423.Google Scholar
Tucker, J.D. (2008) Low-dose ionizing radiation and chromosome translocations: A review of the major considerations for human biological dosimetry, Mutat. Res. 659, 211-220.Google Scholar
UNSCEAR (2008) Sources and effects of ionizing radiation united Nations. N.Y.
Voisin, P., Benderitter, M., Claraz, M., Chambrette, V., Sorokine-Durm, I., Delbos, M., Durand, V., Leroy, A., Paillole, N. (2001) The cytogenetic dosimetry of recent accidental over exposure, Cell Mol. Biol. 47, 557-564.Google Scholar
Wolf, G., Arndt, D., Kotschy-Lang, N., Obe, G. (2004) Chromosomal aberrations in uranium and coal miners, Int. J. Radiat. Biol. 80, 147-153. Google ScholarPubMed
Zakeri, F., Assaei, R.G. (2004) Cytogenetic monitoring of personnel working in angiocardiography laboratories in Iran hospitals, Mutat. Res. 562, 1-9.Google ScholarPubMed