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Anorgasmia from Clomipramine in Obsessive-Compulsive Disorder

A Controlled Trial

Published online by Cambridge University Press:  03 January 2018

W. O. Monteiro ,
H. F. Noshirvani ,
I. M. Marks  and
P.T. Lelliott
W. O. Monteiro
Affiliation:
Institute of Psychiatry; Bethlem & Maudsley Hospitals
H. F. Noshirvani
Affiliation:
Institute of Psychiatry; Bethlem & Maudsley Hospitals
I. M. Marks*
Affiliation:
Institute of Psychiatry; Consultant Psychiatrist, Bethlem & Maudsley Hospitals
P.T. Lelliott
Affiliation:
Institute of Psychiatry; Bethlem & Maudsley Hospitals
*
Institute of Psychiatry, De Crespigny Park, London SE5 8AF
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Extract

Forty-six patients with obsessive-compulsive disorder undergoing a double-blind controlled study of clomipramine and placebo were interviewed to assess changes in sexual function. Of 33 patients with previously normal orgasm, nearly all of the 24 on clomipramine developed total or partial anorgasmia; none of the 9 on placebo did so. Anorgasmia persisted with minimal tolerance over the five months that clomipramine was taken. Men and women were equally affected. Sexual side-effects are easily missed without a structured interview, and can detract from the value of drug treatment.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 1 , July 1987 , pp. 107 - 112
Copyright
Copyright © The Royal College of Psychiatrists 

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