Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T10:36:18.019Z Has data issue: false hasContentIssue false
  • English
  • Français

Cyproheptadine in Anorexia Nervosa

Published online by Cambridge University Press:  29 January 2018

Solomon C. Goldberg ,
Katherine A. Halmi ,
Elke D. Eckert ,
Regina C. Casper  and
John M. Davis
Solomon C. Goldberg
Affiliation:
Psychopharmacology Research Branch, National Institutes of Mental Health, 5600 Fishers Lane, Rm. 9–105, Rockville, Maryland 20852
Katherine A. Halmi
Affiliation:
University of Iowa College of Medicine, 500 Newton Road, Iowa City, Iowa 52242
Elke D. Eckert
Affiliation:
Department of Psychiatry, University of Minnesota Hospitals, Box 393 Mayo Bldg, Minneapolis, Minnesota 55455
Regina C. Casper
Affiliation:
University of Illinois, Illinois State Psychiatric Institute, West Side Medical Center, 1601 W. Taylor Street, Chicago, Illinois 60625
John M. Davis
Affiliation:
University of Chicago, Illinois State Psychiatric Institute, West Side Medical Center, 1601 W. Taylor Street, Chicago, Illinois 60625
Get access Rights & Permissions [Opens in a new window]

Summary

In three hospitals 81 female patients satisfying rigorous diagnostic criteria for anorexia nervosa were randomly allocated to one of four treatment combinations of cyproheptadine and placebo with behaviour therapy and no behaviour therapy. Cyproheptadine was found to be effective in inducing weight gain in a subgroup of anorexia nervosa patients who (a) had a history of birth delivery complications, (b) had lost 41–52 per cent weight from norm and (c) had a history of prior outpatient treatment failure. This subgroup may represent a more severe form of anorexia nervosa.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 134 , Issue 1 , January 1979 , pp. 67 - 70
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Blinder, B. J., Freeman, D. M. & Stunkard, A. J. (1970) Behaviour therapy of anorexia nervosa: effectiveness of activity as a reinforcer of weight gain. American Journal of Psychiatry, 126, 1093–8.Google Scholar
Bruch, H. (1970) Psychotherapy in primary anorexia nervosa. Journal of Nervous and Mental Diseases, 150, 51–67.Google Scholar
Crisp, A. H. (1965) A treatment regimen for anorexia nervosa. British Journal of Psychiatry, 112, 505–12.Google Scholar
Dally, P. N. & Sargent, W. (1960) A new treatment of anorexia nervosa. British Medical Journal, 1, 1770–3.Google Scholar
Goldberg, S. C., Klerman, G. L. & Cole, J. O. (1965) Changes in schizophrenic psychopathology and ward behaviour as a function of phenothiazine treatment. British Journal of Psychiatry, 111, 120–33.Google Scholar
Kuhn, R. (1969) Psychopathology: ‘Pharmacotherapy and psychotherapy of anorexia nervosa’. In Psychotropic Drugs in Internal Medicine (ed. Pletscher, E.), pp. 74–122. Amsterdam: Exerpta Medica Foundation.Google Scholar
Liebman, R., Minuchin, S. & Baker, L. (1974) An integrated treatment programme for anorexia nervosa. American Journal of Psychiatry, 131, 432–6.Google Scholar
Pollin, W., Stabenau, J. R., Mosher, L. & Tupin, J. (1966) Life history differences in identical twins discordant for schizophrenia. American Journal of Orthopsychiatry, 26, 492–509.Google Scholar
Quitkin, F., Rifkin, A. & Klein, D. F. (1976) Neurologic soft signs in schizophrenia and character disorders. Archives of General Psychiatry, 33, 845–53.CrossRefGoogle ScholarPubMed
Raskin, A. & Crook, T. H. (1976) The endogenous-neurotic distinction as a predictor of response to antidepressant drugs. Psychological Medicine, 6, 59–70.Google Scholar
Rollins, N. & Blackwell, A. (1968) The treatment of anorexia nervosa in children and adolescents: stage 1. Journal of Child Psychology and Psychiatry, 9, 81–91.CrossRefGoogle ScholarPubMed
Russell, G. F. M. (1973) The management of anorexia nervosa. From Symposium on Anorexia Nervosa and Obesity, Royal College of Physicians of Edinburgh, 42, 44–62.Google Scholar
Zubiate, Toledo M. (1970) Tratamiento de la anorexia nervosa con una associacion cyproheptadinavitaminas. Rev. Med. Caja Noc. Seguro Soc., 19, 147–53.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.