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Chlordiazepoxide (Librium) A Clinical Trial of its use in Controlling Symptoms of Anxiety

Published online by Cambridge University Press:  29 January 2018

Ronald Maggs  and
Richard Neville
Ronald Maggs
Affiliation:
Hellingly Hospital, Hailsham, Sussex
Richard Neville
Affiliation:
Hellingly Hospital, Hailsham, Sussex, now at Moorhaven Hospital, Ivybridge, South Devon
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Extract

There have been many evaluations of the use of chlordiazepoxide in mental illnesses, most of these concerned with its use in the reduction of anxiety. The majority of the papers have emanated from North America and have reported in “open” investigations that the drug is of value in reducing anxiety. Other papers from Britain, Australia and the European Continent have also described the results of similar treatment. Of the British contributions, only two of eight (Jenner et al., 1961; Gore and McComisky, 1961) describe results of placebo-controlled trials. A recent annotation concerning chlordiazepoxide (1961) observed that most of the trials had not involved the use of placebo. Furthermore, as chlordiazepoxide is a drug very much more expensive than a barbiturate, it was considered that more placebo-controlled investigations were desirable.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 110 , Issue 467 , July 1964 , pp. 540 - 543
Copyright
Copyright © Royal College of Psychiatrists, 1964 

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