Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T07:20:40.088Z Has data issue: false hasContentIssue false
  • English
  • Français

Early intervention, untreated psychosis and the course of early schizophrenia

Published online by Cambridge University Press:  06 August 2018

Donald Linszen ,
Marie Lenior ,
Lieuwe de Haan ,
Peter Dingemans  and
Berthold Gersons
Donald Linszen*
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Marie Lenior
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Lieuwe de Haan
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Peter Dingemans
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Berthold Gersons
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
*
Correspondence: D. Linszen, MD, Psychiatric Centre AMC, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
Get access Rights & Permissions [Opens in a new window]

Abstract

Background Studies have proved that early intervention can delay psychotic relapses, and prevent psychosocial deterioration in people with schizophrenia and related disorders.

Method Our study with young people with recent onset schizophrenia has shown that an intensive intervention programme had a beneficial effect on the occurrence of psychotic relapse and the course of psychotic syndromes. This effect lasted until the end of the 15-month intervention. No significant effect of the two different intervention conditions became apparent.

Results The results of a follow-up study showed that this beneficial effect did not last. Fifteen per cent of the people had a psychotic relapse during the intervention, whereas 64% relapsed during follow-up.

Conclusions These results show that referral to other mental health agencies after intervention is not sufficient and that more support is required to continue disease management, medication compliance and stress management.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 172 , Issue S33: Verging on reality , June 1998 , pp. 84 - 89
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Anderson, C. M., Reiss, D. J. & Hogarty, G. E. (1986) Schizophrenia and the Family. New York: Guilford Press.Google Scholar
Barrelet, L., Ferrero, F., Szigethy, L., et al (1990) Expressed emotion and first-admission schizophrenia, nine-month follow-up in a French cultural environment. British Journal of Psychiatry, 156, 357–362.Google Scholar
Birchwood, M. & MacMillan, J. F. (1993) Early intervention in schizophrenia. Australian and New Zealand Journal of Psychiatry, 27, 374–378.Google Scholar
Breier, A., Schreiber, J. L., Dyer, J., et al (1991) National Institute of Mental Health longitudinal study of chronic schizophrenia: prognosis and predictors of outcome. Archives of General Psychiatry, 48, 239–246.Google Scholar
Crow, T. J., Macmillan, J. F., Johnson, A. L., et al (1986) A randomised clinical trial of prophylactic neuroleptic treatment. British Journal of Psychiatry 148, 120–127.Google Scholar
Dixon, M. J., Brown, M. B., Engelman, L., et al (eds) (1990) BMDP Statistical Software Manual, Vol. I and II. Berkeley, CA: University of California Press.Google Scholar
Falloon, I. R. H., Boyd, J. L. & McGill, C.W. (1984) Family Care of Schizophrenia. New York: Guilford Press.Google Scholar
Häfner, H. & Maurer, K. (1995) Epidemiology of positive and negative symptoms in schizophrenia. Contemporary Issues in Psychiatry 55, 314–335.Google Scholar
Kessler, R. C., Foster, C. L., Saunders, W. B., et al (1995) Social consequences of psychiatric disorders, I: Educational attainment. American Journal of Psychiatry, 152, 1026–1031.Google ScholarPubMed
Kokes, R. F., Strauss, J. S. & Klorman, R. (1977) Premorbid adjustment in schizophrenia: Concept, measures and implications. Part II. Measuring premorbid adjustment: the instruments and their development. Schizophrenia Bulletin, 2, 212–213.Google Scholar
Linszen, D. H., Dingemans, P. M. & Lenior, M. E. (1994a) Cannabis abuse and the course of recent-onset schizophrenic disorders. Archives of General Psychiatry, 51, 273–279.CrossRefGoogle ScholarPubMed
Linszen, D. H., Dingemans, P. M., Lenior, M. E., et al (1994b) Different relapse critieria in schizophrenic disorders. Psychiatry Research, 54, 273–281.Google Scholar
Linszen, D. H., Dingemans, P. M., Scholte, W. F., et al (1996) Treatment, expressed emotion and relapse in recent onset schizophrenic disorders. Psychological Medicine, 26, 333–342.Google Scholar
Linszen, D. H., Dingemans, P. M., Nugter, M. A., et al (1997) Patient attributes and expressed emotion (EE) as risk factors for psychotic relapse. Schizophrenia Bulletin, 23, 119–130.CrossRefGoogle ScholarPubMed
Loebel, A., Alvir, J. M.,Woerner, M., et al (1992) Prospective study of psychobiology of first episode schizophrenia. Schizophrenia Bulletin, 18, 351–371.Google Scholar
MacMillan, J. F., Crow, T. J., Johnson, A. L., et al (1986) Expressed emotion and relapse. British Journal of Psychiatry 148, 133–143.Google Scholar
McGlashan, T. H. (1996) Early detection and intervention in schizophrenia. Schizophrenia Bulletin, 22, 97–200.Google Scholar
McGorry, P. D., Edwards, J., Mihalopoulos, C., et al (1996) EPPIC: an evolving system of early detection and optimal management. Schizophrenia Bulletin, 22, 305–306.Google Scholar
Norusis, M.J. (1990) SPSSPC+ 4.0 Base Manual for the IBM PC/XT/AT and PS/2. Chicago: SPSS Inc.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Report, 10, 799–812.Google Scholar
Schooler, N. R., Keith, S. J., Severe, J. B., et al (1997) Relapse and hospitalization during maintenance treatment of schizophrenia. The effects of dose reduction and family treatment. Archives of General Psychiatry, 54, 453–463.Google Scholar
Van der Does, A. J. W., Dingemans, P. M. A. J., Linszen, D. H., et al (1995) Dimensions and subtypes of recent-onset schizophrenia: a longitudinal analysis. Journal of Nervous Mental Diseases, 103, 681–688.CrossRefGoogle Scholar
Van der Does, A. J. W., Linszen, D. H., Dingemans, P. M. A. J., et al (1993) A dimensional and categorical approach to the symptomatology of recent-onset schizophrenia. Journal of Nervous and Mental Diseases, 181, 744–749.CrossRefGoogle Scholar
World Health Organization (1992) WHO Coordinated Multi-Center Study on the Course and Outcome of Schizophrenia. Geneva: WHO.Google Scholar
Wyatt, R.J. (1991) Neuroleptics and the natural course of schizophrenia. Schizophrenia bulletin, 17, 325–331.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.