Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-10T07:15:02.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial Transmission of Major Affective Disorders

Is there Evidence Supporting the Distinction between Unipolar and Bipolar Disorders?

Published online by Cambridge University Press:  29 January 2018

Ming T. Tsuang ,
Stephen V. Faraone  and
Jerome A. Fleming
Ming T. Tsuang
Affiliation:
Harvard Medical School, Director, Section of Psychiatric Epidemiology and Genetics, Mass. Mental Health Center; Brockton-West Roxbury VA Medical Center, 940 Belmont Street, Brockton, Massachusetts 02401, USA
Stephen V. Faraone
Affiliation:
Section of Psychiatric Epidemiology and Genetics, Mass. Mental Health Center, Harvard Medical School; Health Statistician (Psychiatric Genetics), Brockton-West Roxbury VA Medical Center
Jerome A. Fleming
Affiliation:
Section of Psychiatric Epidemiology and Genetics, Mass. Mental Health Center, Harvard Medical School; Health Statistician (Psychiatry), Brockton-West Roxbury VA Medical Center
Get access Rights & Permissions [Opens in a new window]

Summary

The two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders. This model tested whether bipolar and unipolar disorders are manifestations of the same underlying factors or if they are independently caused disorders. The hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder was supported. There was little evidence for different familial aetiologies for bipolar and unipolar disorders in our sample.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 3 , March 1985 , pp. 268 - 271
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baron, M., Klotz, J., Mendlewicz, J. & Rainer, J. (1981) Multiple-threshold transmission of affective disorders. Archives of General Psychiatry, 38, 79–84.Google Scholar
Bertelsen, A. (1979) In Prevention and Treatment of Affective Disorders, (ed. Schou, M and Stromgren, E.) pp. 227–239, London: Academic Press.Google Scholar
Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish study of manic-depressive disorders. British Journal of Psychiatry, 130, 330–351.Google Scholar
Falconer, D. S. (1965) The inheritance of liability to certain diseases estimated from incidence among relatives. Annals of Human Genetics, 29, 51–76.CrossRefGoogle Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Gershon, E. S., Baron, M. & Leckman, J. F. (1975) Genetic models of the transmission of affective disorders. Journal of Psychiatric Research, 12, 301–317.CrossRefGoogle Scholar
Gershon, E. S., Baron, M. & Hamovit, J., Guroff, J. J., Dibble, E., Leckman, J. F., Sceery, , et al (1982) A family study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands. Archives of General Psychiatry, 39, 1157–1167.Google Scholar
Kaplan, E. B. & Elston, R. C. (1972) A subroutine package for maximum likelihood estimation (MAXLIK). Institute of Statistics Mimeo Series No. 823, University of North Carolina.Google Scholar
Kiloh, L. G. & Garside, R. F. (1963) The independence of neurotic depression and endogenous depression. British Journal of Psychiatry, 109, 451–463.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1974) Morbidity risk and genetic transmission in manic-depressive illness. American Journal of Human Genetics, 26, 692–701.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature, 268, 327–329.Google Scholar
Morrison, J., Clancy, J., Crowe, R. & Winokur, G. (1972) The Iowa 500: I. Diagnostic validity in mania, depression and schizophrenia. Archives of General Psychiatry, 27, 457–461.Google Scholar
Nelson, J. C. & Charney, D. S. (1980) Primary affective disorder criteria and the endogenous-reactive distinction. Archives of General Psychiatry, 37, 787–793.Google Scholar
Perris, C. (1966) A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica, Supplement 194.Google Scholar
Perris, C. (1973) The genetics of affective disorders. In Biological Psychiatry, (ed. Mendels, J.), New York: John Wiley.Google Scholar
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi– continuous traits. Annals of Human Genetics, 36, 163–184.Google Scholar
Reich, T., & Morris, C. A., Rice, J., Cloninger, C. R., Wette, R. & James, J. W. (1979) The use of multiple thresholds and segregation analysis in analyzing the phenotypic heterogeneity of multifactorial traits. Annals of Human Genetics, 42, 371–389.Google Scholar
Tsuang, M. T. (1975) Genetics of affective disorder. In Psychobiology of Depression (ed. Mendels, J.) New York: John Wiley.Google Scholar
Tsuang, M. T., Woolson, R. F. & Fleming, J. A. (1979) Long-term outcome of major psychoses: I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions. Archives of General Psychiatry, 39, 1295–1301.Google Scholar
Tsuang, M. T., Woolson, R. F. & Fleming, J. A. Winokur, G. & Crowe, R. R. (1980a) Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497–504.Google Scholar
Tsuang, M. T., & Fleming, J. A. Winokur, G. & Crowe, R. R., Woolson, R. F. & Simpson, J. C. (1980b) The Iowa Structured Psychiatric Interview: Rationale, reliability and validity. Acta Psychiatrica Scandinavica, Suppl. 283, 62.Google Scholar
Winokur, G., Cadoret, R., Dorzab, J. & Baker, M. (1971) Depressive disease: A genetic study. Archives of General Psychiatry, 24, 135–155.Google Scholar
Zerbin-Rudin, E. (1980) Genetics of affective psychoses. In Handbook of Biological Psychiatry. Part III (ed. van Praag, H. et al). New York: Marcel Dekker.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.