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Huntington's disease: Psychiatric practice in molecular genetic prediction and diagnosis

Published online by Cambridge University Press:  03 January 2018

Jane Scourfield ,
Jo Soldan ,
Jonathon Gray ,
Gary Houlihan  and
Peter S. Harper
Jane Scourfield*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
Jo Soldan
Affiliation:
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff
Jonathon Gray
Affiliation:
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff
Gary Houlihan
Affiliation:
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff
Peter S. Harper
Affiliation:
Institute of Medical Genetics, University of Wales College of Medicine, Cardiff
*
Dr Jane Scourfield, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
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Abstract

Background

Predictive genetic testing for Huntington's disease has been available in Cardiff since 1987 using linked genetic markers, and since 1993 using direct mutation testing, which can also be used as a diagnostic test. During this period there have been numerous referrals that have required liaison with psychiatric services at all stages of the testing programme.

Method

A series of cases was selected to highlight issues from both genetic prediction and diagnosis that are relevant to psychiatric practice and have arisen during the testing programme.

Results

Issues have been raised concerning competence to consent to testing in the context of psychotic illness; depression and suicidal ideation in test candidates; requests for testing from third parties such as psychiatrists, social services and the courts; and testing of children.

Conclusions

As genetic testing becomes possible for more disorders the lessons learned from Huntington's disease will provide valuable guidelines for counselling.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 2 , February 1997 , pp. 146 - 149
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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