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Morbidity Risks of Schizophrenia and Affective Disorders among First Degree Relatives of Patients with Schizophrenia, Mania, Depression and Surgical Conditions

Published online by Cambridge University Press:  29 January 2018

Ming T. Tsuang ,
George Winokur  and
Raymond R. Crowe
Ming T. Tsuang
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine, 500 Newton Road, Iowa City, Iowa 52242, U.S.A.
George Winokur
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine
Raymond R. Crowe
Affiliation:
Department of Psychiatry, University of Iowa College of Medicine
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Summary

One thousand five hundred and seventy eight first degree relatives of schizophrenics, manics, depressives and controls were personally interviewed using the Iowa Structured Psychiatric Interview Form without knowledge of the probands' diagnoses. Our data, based on blind diagnostic assessment of the relatives, support the distinction between schizophrenia and affective disorders, although the distinction between schizophrenia and mania was not clear-cut. Our data could not support familial subtyping of paranoid and non-paranoid schizophrenia, and unipolar and bipolar affective disorders. Future studies attempting to develop research criteria for subtyping schizophrenia and affective disorders should utilize not only clinical and familial data but also biological markers and other non-familial variables.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 6 , December 1980 , pp. 497 - 504
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Elston, R. C. & Yelverton, K. C. (1975) General models for segregation analysis. American Journal of Human Genetics, 27, 31–45.Google Scholar
Elston, R. C. & Sobel, E. (1979) Sampling considerations in the gathering and analysis of pedigree data. American Journal of Human Genetics, 31, 62–69.Google Scholar
Feighner, J. P. Robins, E. Guze, S. B. Woodruff, R. A. Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Morrison, J. Clancy, J. Crowe, R. & Winokur, G. (1972) The Iowa 500: I. Diagnostic validity in mania, depression and schizophrenia. Archives of General Psychiatry, 27, 457–461.Google Scholar
Reich, T. Cloninger, C. R. & Guze, S. B. (1975) The multifactorial model of disease transmission: I. Description of the model and its use in psychiatry. British Journal of Psychiatry, 127, 1–10.Google Scholar
Reich, T. Rice, J. Cloninger, C. R. Wette, R. & James, J. (1979) The use of multiple thresholds and segregation analysis in analyzing the phenotypic heterogeneity of multifactorial traits. Annals of Human Genetics, 42, 371–389.Google Scholar
Slater, E. & Cowie, V. A. (1971) The Genetics of Mental Disorders. pp 31–32. London: Oxford University Press.Google Scholar
Tsuang, M. T. & Winokur, G. (1974) Criteria for subtyping Schizophrenia: Clinical differentiation of hebephrenic and paranoid schizophrenia. Archives of General Psychiatry, 31, 43–47.CrossRefGoogle ScholarPubMed
Tsuang, M. T. & Woolson, R. F. (1977) Mortality in patients with schizophrenia, mania, depression and surgical conditions: A comparison with general population mortality. British Journal of Psychiatry, 130, 162–166.CrossRefGoogle ScholarPubMed
Tsuang, M. T. Woolson, R. F. & Fleming, J. A. (1979) Long-term outcome of major psychoses: I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions. Archives of General Psychiatry, 39, 1295–1301.Google Scholar
Tsuang, M. T. Woolson, R. F. & Simpson, J. C. (1980) The Iowa structured psychiatric interview: Rationale, reliability, and validity. Acta Psychiatrica Scandinavica, Suppl 283, Vol. 62.Google Scholar
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