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The Psychiatric Status of Patients with the Chronic Fatigue Syndrome

Published online by Cambridge University Press:  03 January 2018

Ian Hickie ,
Andrew Lloyd ,
Denis Wakefield  and
Gordon Parker
Ian Hickie*
Affiliation:
Mood Disorders Unit, Division of Psychiatry, Prince Henry Hospital, Sydney, 2036 Australia
Andrew Lloyd
Affiliation:
School of Pathology, University of New South Wales, Kensington NSW, Australia
Denis Wakefield
Affiliation:
School of Pathology, University of New South Wales, Kensington NSW, Australia
Gordon Parker
Affiliation:
School of Psychiatry (University of New South Wales), Prince Henry Hospital, Sydney, Australia
*
∗Correspondence
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Abstract

The prevalence of psychiatric disorder in 48 patients with chronic fatigue syndrome (CFS) was determined. Twenty-two had had a major depressive (non-endogenous) episode during the course of their illness, while seven had a current major (non-endogenous) depression. The pre-morbid prevalence of major depression (12.5%) and of total psychiatric disorder (24.5%) was no higher than general community estimates. The pattern of psychiatric symptoms in the CFS patients was significantly different to that of 48 patients with non-endogenous depression, but was comparable with that observed in other medical disorders. Patients with CFS were not excessively hypochrondriacal. We conclude that psychological disturbance is likely to be a consequence of, rather than an antecedent risk factor to the syndrome.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 156 , Issue 4 , April 1990 , pp. 534 - 540
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised). Washington, DC: APA.Google Scholar
Behan, P. O., Behan, W. M. H. & Bell, E. J. (1985) The postviral fatigue syndrome – analysis of the findings in 50 cases. Journal of Infection, 10, 211–222.CrossRefGoogle ScholarPubMed
Bridges, K. W. & Goldberg, D. P. (1984) Psychiatric illness in inpatients with neurological disorders: patients' views on discussion of emotional problems with neurologists. British Medical Journal, 289, 656–658.CrossRefGoogle ScholarPubMed
Bromet, E. J., Dunn, L. O., Connell, M. M., et al (1986) Long-term reliability of diagnosing lifetime major depression in a community sample. Archives of General Psychiatry, 43, 435–440.CrossRefGoogle Scholar
Caliguiri, M., Murray, C., Buchwald, D., et al (1987) Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. Journal of Immunology, 139, 3306–3313.Google Scholar
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive symptoms and the prediction of ECT response. British Journal of Psychiatry, 111, 659–674.Google Scholar
Congalton, A. A. (1969) Status and Prestige in Australia. Melbourne: F. W. Cheshire Publishing Pty Ltd.Google Scholar
David, A. S., Wessely, S. & Pelosi, A. J. (1988) Postviral fatigue syndrome: time for a new approach. British Medical Journal, 296, 696–699.CrossRefGoogle ScholarPubMed
Dawson, J. (1987) Royal Free disease: perplexity continues (editorial). British Medical Journal, 294, 327–328.Google Scholar
Denicoff, K. D., Rubinow, D. R., Papa, M. Z., et al (1987) The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Annals of Internal Medicine, 107, 293–300.Google Scholar
Eysenck, H. J. & Eysenck, S. B. (1964) Manual of the Eysenck Personality Inventory. London: Hodder & Stoughton.Google Scholar
Goldberg, D. P. (1979) Manual of the General Health Questionnaire. Windsor: NFER Publishing Co.Google Scholar
Goldberg, D. P. & Blackwell, B. (1970) Psychiatric illness in general medical practice. British Medical Journal, ii, 439–443.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.Google Scholar
Holmes, G. P., Kaplan, J. E., Gantz, N. M., et al (1988) Chronic fatigue syndrome: a working case definition. Annals of Internal Medicine, 108, 387–389.Google Scholar
Kraepelin, E. (1981) Clinical Psychiatry (ed. Watson, R. I.). New York: Scholars' Facsimiles & Reprints.Google Scholar
Kruesi, M. J. P., Dale, J. & Straus, S. E. (1989) Psychiatric diagnoses in patients who have chronic fatigue syndrome. Journal of Clinical Psychiatry, 50, 53–56.Google ScholarPubMed
Krupp, L. B., Alvarez, L. A., LaRocca, N. G., et al (1988) Fatigue in multiple sclerosis. Archives of Neurology, 45, 435–437.Google Scholar
Lloyd, A. R., Hales, J. P. & Gandevia, S. C. (1988a) Muscle strength, endurance and recovery in the post-infection fatigue syndrome. Journal of Neurology, Neurosurgery, and Psychiatry, 51, 1316–1322.CrossRefGoogle ScholarPubMed
Lloyd, A. R., Wakefield, D., Boughton, C., et al (1988b) What is myalgic encephalomyelitis? Lancet, i, 1286–1287.Google Scholar
Lloyd, A. R., Wakefield, D., Boughton, C., et al (1989) Immunological abnormalities in the chronic fatigue syndrome. Medical Journal of Australia, 151, 122–124.Google Scholar
Maguire, G. P., Julier, D. L., Hawton, K. E., et al (1974) Psychiatric morbidity and referral on two general medical wards. British Medical Journal, i, 268–70.Google Scholar
Manu, P., Lane, T. J. & Matthews, D. A. (1988) The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue. Annals of Internal Medicine, 109, 554–556.Google Scholar
McDonald, E. M., Mann, A. H. & Thomas, H. C. (1987) Interferons as mediators of psychiatric morbidity. An investigation in a trial of recombinant α-interferon in hepatitis-B carriers. Lancet, ii, 1175–1177.Google Scholar
McEvedy, C. P. & Beard, A. W. (1973) A controlled follow-up of cases involved in an epidemic of benign myalgic encephalomyelitis. British Journal of Psychiatry, 122, 141–150.CrossRefGoogle Scholar
Pilowsky, I. (1988) Abnormal illness behaviour. In Handbook of Social Psychiatry (eds Henderson, A. S. & Burrows, G.). Amsterdam: Elsevier Science publishers.Google Scholar
Pilowsky, I. & Spence, N. D. (1983) Manual for the Illness Behaviour Questionnaire (IBO) (2nd edn). Adelaide: University of Adelaide.Google Scholar
Reich, T., Rice, J., Andreasen, N., et al (1980) A preliminary analysis of the segregation distribution of primary major depressive disorder. Psychological Bulletin, 16, 34–36.Google Scholar
Robins, L. N., Helzer, J. E., Weissman, M. M., et al (1984) Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry, 41, 949–958.Google Scholar
Singer, A., Thompson, S., Kraiuhin, C., et al (1988) An investigation of patients presenting with multiple physical complaints using the Illness Behaviour Questionnaire. Psychotherapy and Psychosomatics, 47, 181–189.CrossRefGoogle Scholar
Spitzer, R. L. & Williams, J. B. W. (1985) Structured Clinical Interview for DSM–III–R, Patient Version (SCID-P, 7/1/85). New York: Biometrics Research Dept, Psychiatric Institute.Google Scholar
Straus, S. E. (1988) The chronic mononucleosis syndrome. Journal of Infectious Diseases, 157, 405–412.CrossRefGoogle ScholarPubMed
Straus, S. E., Tosato, G., Armstrong, G., et al (1985) Persisting fatigue and illness in adults with evidence of persisting Epstein–Barr virus infection. Annals of Internal Medicine, 102, 7–16.CrossRefGoogle ScholarPubMed
Swartz, M. N. (1988) The chronic fatigue syndrome – one entity or many (editorial)? New England Journal of Medicine, 319, 1726–1728.Google Scholar
Taerk, G. S., Toner, B. B., Salit, I. E., et al (1987) Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis). International Journal of Psychiatry in Medicine, 17, 49–56.CrossRefGoogle ScholarPubMed
Wakefield, D. & Lloyd, A. (1987) Pathophysiology of myalgic encephalomyelitis. Lancet ii, 918–919.CrossRefGoogle Scholar
Weissman, M. M., Myers, J. K. & Harding, P. S. (1978) Psychiatric disorders in a US urban community: 1975–76. American Journal of Psychiatry, 135, 459–462.Google Scholar
Yousef, G. E., Bell, E. J., Mann, G. F., et al (1988) Chronic enterovirus infection in patients with postviral fatigue syndrome. Lancet, i, 146–149.Google Scholar
Zung, W. W. K. (1965) A self-rating depression scale. Archives of General Psychiatry, 12, 63–70.Google Scholar
Zung, W. W. K. (1972) How normal is depression? Psychosomatics, 12, 174–178.Google Scholar
Zung, W. W. K., Magill, M., Moore, J. T., et al (1983) Recognition and treatment of depression in a family medicine practice. Journal of Clinical Psychiatry, 44, 3–6.Google Scholar
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