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Quantitative Brain Measurements in Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Randall Rosenthal  and
Llewellyn B. Bigelow
Randall Rosenthal
Affiliation:
Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington D.C., 20032
Llewellyn B. Bigelow
Affiliation:
Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington D.C., 20032
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Extract

Despite extensive gross and microscopic scrutiny, no consistent pathological findings have emerged from studies of autopsy material from schizophrenic patients. Dunlap (1924) carried out the first controlled study involving schizophrenic and control brains and concluded that ‘there was not even a suspicion of consistent organic brain disease as a basis for the psychosis of schizophrenia’. More recently both Wolf and Cowen (1952), and Weinstein (1954), reviewed the neuropathological literature and concluded that there were no consistent findings at autopsy that could be construed as characteristic of schizophrenia. These authors felt that earlier claims were based on failure to appreciate the range of normal variation in the brain as well as a failure to include an adequate control population in the study.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 121 , Issue 562 , September 1972 , pp. 259 - 264
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

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