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Relationships in Healthy Volunteers Between Concentrations of Monoamine Metabolites in Cerebrospinal Fluid and Family History of Psychiatric Morbidity

Published online by Cambridge University Press:  29 January 2018

Göran Sedvall ,
Bengt Fyrö ,
Bo Gullberg ,
Henrik Nybäck ,
Frits-Axel Wiesel  and
Birgitta Wode-Helgodt
Göran Sedvall*
Affiliation:
Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Institutet, S–104 01 Stockholm, Sweden
Bengt Fyrö
Affiliation:
Department of Psychiatry, St Göran's Hospital, S–112 81 Stockholm, Sweden
Bo Gullberg
Affiliation:
Department of Statistics, University of Lund, S–220 05 Lund, Sweden
Henrik Nybäck
Affiliation:
Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Institutet, S–104 01 Stockholm, Sweden
Frits-Axel Wiesel
Affiliation:
Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Institutet, S–104 01 Stockholm, Sweden
Birgitta Wode-Helgodt
Affiliation:
Department of Psychiatry, St Göran's Hospital S–112 81 Stockholm, Sweden
*
∗Correspondence.
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Summary

In 60 physically and mentally healthy human subjects, lumbar cerebrospinal fluid was analysed by mass fragmentography for 5-HIAA, HVA and MOPEG. Individuals with a family history of psychiatric morbidity had significantly greater variation in monoamine metabolite concentrations than subjects without such a family history. In subjects with a family history of schizophrenic psychosis 5-HIAA and HVA concentrations were significantly higher than in subjects with depressive disorders within the family. For subjects with deviant 5-HIAA levels the probability of having a psychiatric family history was 2.7 times higher than in subjects with normal values. For HVA and MOPEG similar relationships, but of a lower significance level, were found. The results suggest that the cerebral monoaminergic transmitter amines play critical roles in the pathophysiology of psychotic and depressive disorders with a family disposition. They also indicate a value of monoamine metabolite determination in CSF for the prediction of family vulnerability for psychiatric morbidity in healthy subjects.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 136 , Issue 4 , April 1980 , pp. 366 - 374
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Åsberg, M. & Bertilsson, L. (1979) Serotonin in depressive illness—Studies of CSF 5-HIAA. In Proceedings of the XI CINP Congress. Oxford: Pergamon Press. (In press).Google Scholar
Åsberg, M., Bertilsson, L., Tuck, D., Cronholm, B. & Sjöqvist, F. (1973) Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline. Clinical Pharmacology and Therapeutics, 14, 277–86.Google Scholar
Åsberg, M., Perris, C., Schalung, D. & Sedvall, G. (1978) The CPRS—Development and applications of a psychiatric rating scale. Acta Psychiatrica Scandinavica, Suppl. 271.Google Scholar
Åsberg, M., Thoren, P., Träskman, L., Bertilsson, L. & Ringberger, V. (1976a) ‘Serotonin depression’—a biochemical subgroup within the affective disorders? Science, 191, 478–80.CrossRefGoogle ScholarPubMed
Åsberg, M., Träskman, L. & Thoren, P. (1976b) 5-HIAA in the cerebrospinal fluid—a biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–7.CrossRefGoogle ScholarPubMed
Bertilsson, L. (1973) Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography. Journal of Chromatography, 87, 147–53.Google Scholar
Bertilsson, L., Atkinson, A. J. Jr., Althaus, J. R., Härfast, Å., Lindgren, J.-E. & Holmstedt, B. (1972) Quantitative determination of 5-hydroxyindole-3-acetic acid in cerebrospinal fluid by gas chromatography-mass spectrometry. Analytical Chemistry, 44, 1434–8.Google Scholar
Bertilsson, L., Åsberg, M. & Thoren, P. (1974) Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression. European Journal of Clinical Pharmacology, 7, 365–8.CrossRefGoogle ScholarPubMed
Bjerkenstedt, L., Härnryd, C., Grimm, V., Gullberg, B. & Sedvall, G. (1978) A double-blind comparison of melperone and thiothixene in psychotic women using a new rating scale, the CPRS. Archives of Psychiatry and Neurological Sciences, 226, 157–72.Google Scholar
Bowers, M. B. (1972) Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline. Psychopharmacologia, 23, 26–33.Google Scholar
Carlsson, A. (1978) Antipsychotic drugs, neurotransmitters and schizophrenia. American Journal of Psychiatry, 135, 164–73.Google Scholar
Coppen, A. (1972) Indoleamines and affective disorders. Journal of Psychiatric Research, 9, 163–71.Google Scholar
Feinstein, A. R. (1974) The derangements of the ‘range of normal’. Clinical Pharmacology and Therapeutics, 15, 528–40.CrossRefGoogle ScholarPubMed
Fleiss, J. L. (1973) Statistical methods for rates and proportions. New York: John Wiley.Google Scholar
Garelis, E. & Sourkes, T. L. (1973) Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid. Journal of Neurology, Neurosurgery, and Psychiatry, 36, 625–9.Google Scholar
Gottfries, C. G., Gottfries, I., Johansson, B., Olsson, R., Persson, T., Roos, B.-E. & Sjöström, R. (1971) Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex. Neuropharmacology, 10, 665–72.Google Scholar
Gottfries, C. G., Gottfries, I. & Roos, B.-E. (1969) Homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid of patients with senile dementia, presenile dementia and parkinsonism. Journal of Neurochemistry, 16, 1341–5.CrossRefGoogle ScholarPubMed
Kety, S. S., Rosenthal, D., Wender, P. H., Schulsinger, F. & Jacobsen, B. (1975) Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based on psychiatric interviews. In Genetic Research in Psychiatry (eds. Fieve, R., Rosenthal, D. and Brill, N.). Johns Hopkins University Press, Baltimore, pp 147–65.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–75.Google Scholar
Matthysse, S. & Lipinski, J. (1975) Biochemical aspects of schizophrenia. Annual Review of Medicine, 26, 551–65.Google Scholar
Mendlewicz, J. & Rainer, J. D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature, 268, 327–9.CrossRefGoogle ScholarPubMed
Miettinen, O. S. (1976) Stratification by a multivariate confounder score. American Journal of Epidemiology, 104, 60–620.CrossRefGoogle ScholarPubMed
Praag, H. M. van (1974) Towards a biochemical typology of depression? Pharmakopsychiatrie, 7, 281–92.Google Scholar
Sedvall, G., Alfredsson, G., Swahn, C.-G., Wiesel, F.-A. & Wode-Helgodt, B. (1975) Selective effects of psychoactive drugs on levels of monoamine metabolites and prolactin in cerebrospinal fluid of psychiatric patients. In Proceedings of the Sixth International Congress of Pharmacology, (ed. Airaksinen, M.). Forssan Kirjapaino Y Oy, Forssa, Vol. 3, 255–67.Google Scholar
Sedvall, G., Bjerkenstedt, L., Swahn, C.-G., Wiesel, F.-A. & Wode-Helgodt, B. (1977) Mass fragmentography to study dopamine metabolism. In Advances in Biochemical Psychopharmacology, Vol. 16, 343–8 (eds. Costa, E. and Gessa, G. L.). New York: Raven Press.Google Scholar
Sedvall, G., Fyrö, B., Nybäck, H., Wiesel, F.-A. & Wode-Helgodt, B. (1974) Mass fragmentometric determination of homovanillic acid in lumbar cerebrospinal fluid of schizophrenic patients during treatment with antipsychotic drugs. Journal of Psychiatric Research, 11, 75–80.CrossRefGoogle ScholarPubMed
Sedvall, G. & Wode-Helgodt, B. (1979) Relationships in schizophrenic patients between aberrant monoamine metabolite concentration in cerebrospinal fluid and family history of the disorder. Submitted for publication.Google Scholar
Sjöquist, B. & Johansson, B. (1978) A comparison between fluorometric and mass fragmentographic determination of homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Journal of Neurochemistry, 31, 621–5.CrossRefGoogle ScholarPubMed
Sjöquist, B. & Änggård, E. (1972) Gas chromatographic determination of homovanillic acid in human cerebrospinal fluid by electron capture detection and by mass fragmentography with a deuterated internal standard. Analytical Chemistry, 44, 2297–301.Google Scholar
Sjöström, R. & Roos, B.-E. (1972) 5-Hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis. European Journal of Clinical Pharmacology, 4, 170–6.CrossRefGoogle ScholarPubMed
Stabenau, J. R. (1977) Genetic and other factors in schizophrenic, manic-depressive and schizo-affective psychoses. The Journal of Nervous and Mental Disease, 164, 149–67.CrossRefGoogle ScholarPubMed
Swahn, C.-G., Sandgärde, B., Wiesel, F.-A. & Sedvall, G. (1976) Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method. Psychopharmacology, 48, 147–52.CrossRefGoogle Scholar
Walsh, J. E. (1965) Handbook of nonparametric statistics II, p 151. Princeton: D. Van Nostrand Company.Google Scholar
Vestergaard, P., Sørensen, T., Hoppe, E., Rafaelsen, O. J., Yates, C. M. & Nicolaou, N. (1978) Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders. Acta Psychiatrica Scandinavica, 58, 88–96.Google Scholar
Wode-Helgodt, B., Fyrö, B., Gullberg, B. & Sedvall, G. (1977) Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients. Acta Psychiatrica Scandinavica, 56, 129–42.Google Scholar
Wode-Helgodt, B. & Sedvall, G. (1978) Correlations between height of subject and concentration of monoamine metabolites in cerebrospinal fluid from psychotic men and women. Communications in Psychopharmacology, 2, 177–83.Google Scholar
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