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The Use of Imipramine (“Tofranil”) and Other Psychotropic Drugs in Organic Emotionalism

Published online by Cambridge University Press:  29 January 2018

Ian R. Lawson  and
Robin D. M. MacLeod
Ian R. Lawson
Affiliation:
The Glenburn Wing, Woodend Hospital, Aberdeen
Robin D. M. MacLeod
Affiliation:
Aberdeen General Hospitals: Geriatric Unit, Eastern General Hospital, Edinburgh
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Extract

Emotionalism, occurring as excessive or inappropriate weepiness or laughter, is a common and distressing symptom of the pseudobulbar state. It interferes with conversation, is socially embarrassing, and occurring during eating or drinking can be dangerous, particularly so in a patient already dysphagia Preliminary and uncontrolled use of imipramine in a few cases of this condition impressed us with its efficacy, and we therefore engaged in a “double-blind” form of therapeutic trial, comparing two dose strengths of imipramine with phenobarbitone and dummy tablets given in random sequence to each patient. Our favourable impression of imipramine being confirmed, we then attempted to assess the effect on this symptom of two other drugs of related pharmacology.

Type
Organic Psychoses
Information
The British Journal of Psychiatry , Volume 115 , Issue 520 , March 1969 , pp. 281 - 285
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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References

Himwich, H. (1965). In The Scientific Basis of Drug Therapy in Psychiatry. Edited by Marks, J. and Pare, C. M. B. Pergamon: London.Google Scholar
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