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Biologically active peptides derived from egg proteins

Published online by Cambridge University Press:  28 June 2013

E. ECKERT
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
A. ZAMBROWICZ*
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
M. POKORA
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
A. POLANOWSKI
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
J. CHRZANOWSKA
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
M. SZOLTYSIK
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
A. DĄBROWSKA
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
H. RÓŻAŃSKI
Affiliation:
The State School of Higher Professional Education, Krosno, Poland
T. TRZISZKA
Affiliation:
Dept. of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
*
Corresponding author: graszkiewicz@o2.pl
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Abstract

During food processing, proteins are subjected to different modifications, of which most are the result of proteolytic enzyme activity. Due to these mild and easily controlled reaction conditions, this method of modification has been commonly applied in producing high quality food products. Processing affects the conformation of the molecule and its biological activity. Limited hydrolysis leads to improvement of both the functional and nutritional properties of proteins, as well as their organoleptic characteristics. Proteolytic enzymes release peptides that frequently show different specific biological activities. Bioactive peptides govern the function of other compounds in the bloodstream, digestive, immune and nervous systems. Food sources of bioactive peptides exhibiting anti-hypertensive, anti-tumour, antioxidant or antimicrobial activities include milk, eggs and fish. Biopeptides with specific biological activities can be used in pharmaceutical, cosmetic or food industries as natural substances which prevent adverse changes, as food additives or as functional food ingredients with defined benefits to the consumer. The following paper reviews the role of hens eggs as a source of bioactive peptides, and how these can be used in functional foods.

Type
Review Article
Copyright
Copyright © World's Poultry Science Association 2013

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References

ABDOU, A.M., HIGASHIGUCHI, S., ABOUELEININ, A.M., KIM, M. and IBRAHIM, H.R. (2007) Antimicrobial peptides derived from hen egg lysozyme with inhibitory effect against Bacillus species. Food Control 18: 173-178.CrossRefGoogle Scholar
AGYARE, K.K., XIONG, Y.L. and ADDO, K. (2008) Influence of salt and pH on the solubility and structural characteristics of transglutaminase-treated wheat gluten hydrolysate. Food Chemistry 107(3): 1131-1137.Google Scholar
AZUMA, N., SUDA, H., IWASAKI, H., YAMAGATA, N., SAEKI, T. and KANAMOTO, R. (2000) Antitumourigenic effects of several food proteins in a rat model with colon cancer and their reverse correlation with plasma bile acid concentration. Journal of Nutritional Science & Vitaminology 46: 91-96.CrossRefGoogle Scholar
BELOBRAJDIC, D.P., MCINTOSH, G.H. and OWENS, J.A. (2003) Whey proteins protect more than red meat against azoxymethane induced ACF in wistar rats. Cancer Letters 198: 43-51.CrossRefGoogle ScholarPubMed
BIZIULEVIĊIUS, G.A., KISLUKHINA, O.V., KAZLAUSKAITÉ, J. and ŻUKAITÉ, V. (2006) Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality. FEMS Immunology and Medical Microbiology 46(1): 131-138.CrossRefGoogle Scholar
BOUHALLAB, S., CINGA, V., AIT-OUKHATAR, N., BUREAU, F., NEUVILLE, D. and ARHAN, P. (2002) Influence of various phosphopeptides of caseins on iron absorption. Journal of Agricultural and Food Chemistry 50: 7127-7130.CrossRefGoogle ScholarPubMed
CÓRDOVA-MURUETA, J.H., NAVARRETE-DEL-TORO, M.A. and GARCIA-CARRENO, F.L. (2007) Concentrates of fish protein from by catch species produced by various drying processes. Food Chemistry 100: 05-711.CrossRefGoogle Scholar
CHAN, D.I., PRENNER, E.J. and VOGEL, H.J. (2006) Tryptophan- and arginine- rich antimicrobial peptides: Structures and mechanisms of action. Biochimica et Biophysica Acta (BBA) - Biomembranes 1758: 1184-1202.CrossRefGoogle ScholarPubMed
CHANG, C.Y., WU, K.C. and CHIANG, S.H. (2007) Antioxidant properties and protein compositions of porcine hemoglobin hydrolysates. Food Chemistry 100: 1537-1543.CrossRefGoogle Scholar
CHAVAKIS, T., BOECKEL, N., SANTOSO, S., VOSS, R., ISORIDA-SALAS, I. and PIXLEY, R.A. (2002) Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys 502) of high molecular weight kininogen. Journal of Biological Chemistry 277: 57-64.CrossRefGoogle ScholarPubMed
CHOI, I., JUNG, C., CHOI, H., KIM, C. and HA, H. (2005) Effectiveness of phosvitin peptides on enhancing bioavailability of calcium and its accumulation in bones. Food Chemistry 93: 577-583.CrossRefGoogle Scholar
CLEMENTE, A. (2000) Enzymatic protein hydrolysates in human nutrition. Trends in Food Science & Technology 11(7): 254-262.CrossRefGoogle Scholar
CROSS, K.J., HUQ, N.L. and REYNOLDS, E.C. (2007) Casein phosphopeptides in oral health-chemistry and clinical applications. Current Pharmaceutical Design 13: 793-800.CrossRefGoogle ScholarPubMed
DAVALÕS, A., MIGIEL, M., BARTOLOME, B. and LÓPEZ–FANDIŇO, R. (2004) Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. Journal of Food Products 67: 1939-1944.CrossRefGoogle ScholarPubMed
DAVIS, C. and REEVES, R. (2002) High value opportunities from the chicken egg. A report for the Rural Industries Research and Development Corporation 02/094.Google Scholar
DUARTE DE HOLANDA, H. and NETTO, F.M. (2006) Recovery of components from shrimp (Xiphopenaeus kroyeri) processing waste by enzymatic hydrolysis. Journal of Food Science 71(5): 298-303.Google Scholar
ELIAS, R.J., KELLERBY, S.S. and DECKER, E.A. (2008) Antioxidant activity of proteins and peptides. Critical Reviews in Food Science and Nutrition 48: 430-441.CrossRefGoogle ScholarPubMed
ERDMAN, K., CHEUNG, B.W.Y. and SCHRÖDER, H. (2008) The possible roles of food-derived peptides in reducing in the risk of cardiovascular disease. Journal of Nutritional Biochemistry 19: 643-654.CrossRefGoogle Scholar
FERRER, J., PAEZ, G., MARMOL, Z., RAMONES, E., GARCIA, H. and FORSTER, C.F. (1996) Acid hydrolysis of shrimp-shell wastes and the production of single cell protein from the hydrolysate. Bioresource Technology 57: 55-60.CrossRefGoogle Scholar
FITZGERALD, R.J. and O'CUINN, G. (2000) Enzymatic debittering of food protein hydrolysates. Biotechnology Advances 24(2): 234-237.Google Scholar
FUJITA, H., SASAKI, R. and YOSHIKAWA, M. (1995) Potentiation of the antihypertensive activity of orally administered ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidylcholine. Bioscience Biotechnology & Biochemistry 59(12): 2344-2345.CrossRefGoogle Scholar
GAUTHIER, S.F., POULIOT, Y. and SAINT-SAUVEUR, D. (2006) Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. International Dairy Journal 16(11): 1315-1323.CrossRefGoogle Scholar
GIBBS, B.F., ZOUGMAN, A., MASSE, R. and MULLIGAN, C. (2004) Production and characterization of bioactive peptides from soy hydrolysate and soy–fermented food. Food Research International 37: 123-131.CrossRefGoogle Scholar
HANCOCK, R.E.W. and SAHL, H.G. (2006) Antimicrobial and hostdefense peptides as new anti-infective therapeutic strategies. Nature Biotechnology 24(12): 1551-1557.CrossRefGoogle Scholar
HARTMAN, R. and MIESEL, H. (2007) Food-derived peptides with biological activity: from research to food applications. Current Opinion in Biotechnology 18: 163-169.CrossRefGoogle Scholar
HERNANDEZ-LEDESMA, B., DAVALOS, A., BARTOLOME, B. and AMIGO, L. (2005) Preparation of antioxidant enzymatic hydrolysates from alpha-lactalbumin and beta-lactoglobulin. Identification of active peptides by HPLC-MS/MS. Journal of Agricultural and Food Chemistry 53: 588-593.CrossRefGoogle ScholarPubMed
IBRAHIM, H.R., IWAMORI, E., SUGIMOTO, Y. and AOKI, T. (1998) Identification of a distinct antibacterial domain within the N-lobe of ovotransferrin. Biochimica et Biophysica Acta (BBA) – Biomembranes 1401(3): 289-303.CrossRefGoogle Scholar
IBRAHIM, H.R., SUGIMOTO, Y. and AOKI, T. (2000) Ovotransferrin antimicrobial peptide (OTAP-92) kills bacteria through a membrane damage mechanism. Biochimica et Biophysica Acta 1523: 196-205.CrossRefGoogle ScholarPubMed
ISHIKAWA, S., ASANO, T., TAKENOSHITA, S., NOZAWA, Y., ARIHARA, K. and ITOH, M. (2009) Egg yolk proteins suppress azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colon of rats. Nutrition Research 29: 64-69.CrossRefGoogle ScholarPubMed
ISHIKAWA, S., YANO, Y., ARIHARA, K. and ITOH, M. (2004) Egg yolk phosvitin inhibits hydroxyl radical formation from Fenton reaction. Bioscience Biotechnology & Biochemistry 68: 1324-31.CrossRefGoogle ScholarPubMed
IWANIAK, A. and MINKIEWICZ, P. (2007) Proteins as the source of physiologically and functionally active peptides. ACTA Scientiarum Polonorum - Technologia Alimentaria 6(3): 5-15.Google Scholar
JE, J.Y., QIAN, Z.J., BYUN, H.G. and KIM, S.K. (2007) Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis. Process Biochemistry 42: 840-846.CrossRefGoogle Scholar
JIANG, B. and MINE, Y. (2001) Phosphopeptides derived from hen egg yolk phosvitin: effect of molecular size on the calciumbinding properties. Bioscience Biotechnology & Biochemistry 65: 1187-1190.CrossRefGoogle ScholarPubMed
JONES, L.J. and TUNG, M.A. (1983) Functional properties of protein of modified oil seed protein concentrates and isolates. Canadian Institute of Food Science and Technology Journal 16: 57-62.CrossRefGoogle Scholar
KATAYAMA, S., ISHIKAWA, S., FAN, M.Z. and MINE, Y. (2007) Oligophosphopeptides derived from egg yolk phosvitin up-regulate gamma-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells. Journal of Agricultural and Food Chemistry 55: 28,29-35.CrossRefGoogle ScholarPubMed
KATAYAMA, S., XU, X., FAN, M.Z. and MINE, Y. (2006) Antioxidative stress activity of oligophosphopeptides derived from hen egg yolk phosvitin in Caco-2 cells. Journal of Agricultural and Food Chemistry 54: 773-778.CrossRefGoogle ScholarPubMed
KAWASHIMA, K., ITOH, H., MIYOSHI, M. and CHIBATA, I. (1979) Antioxidant properties of branched-chain amino acid derivatives. Chemical & Pharmaceutical Bulletin (Tokyo) 27: 1912-1916.CrossRefGoogle ScholarPubMed
KIM, S.B., SEO, I.S., KHAN, M.A., KI, K.S., NAM, M.S. and KIM, H.S. (2007) Separation of iron-binding protein from whey trough enzymatic hydrolysis. International Dairy Journal 17: 625-631.CrossRefGoogle Scholar
KOŁAKOWSKI, E., BEDNARSKI, W. and BIELECKI, S. (2005) Enzymatyczna modyfikacja składników żywności. Wydaw. A. R. Szczecin: 373-382 (in polish).Google Scholar
KONG, B.H. and XIONG, Y.L. (2006) Antioxidant activity of zein hydrolysates in a liposome system and the possible mode of action. Journal of Agricultural and Food Chemistry 54: 6059-6068.CrossRefGoogle Scholar
KONG, X., ZHOU, H. and QIAN, H. (2007) Enzymatic hydrolysis of wheat gluten by proteases and properties of the resulting hydrolysates. Food Chemistry 102: 759-763.CrossRefGoogle Scholar
KORHONEN, H. and PIHLANTO, A. (2003) Food-derived bioactive peptides—opportunities for designing future foods. Current Pharmaceutical Design 9: 1297-308.CrossRefGoogle ScholarPubMed
KUNST, T. (2003) Protein modification to optimize functionality protein hydrolysates, in: WHITAKER, J.R., VORAGEN, A.G.J. & WONG, D.W.S. (Eds) Handbook of Enzymology, pp. 221-231 (New York, Basel).Google Scholar
LEE, N.Y., CHENG, J.T., ENOMOTO, T. and NAKANO, Y. (2006) One peptide derived from hen ovotransferrin as pro-drug to inhibit angiotensin converting enzyme. Journal of Food and Drug Analysis 14: 31-35.Google Scholar
LI, B., CHEN, F., WANG, X., JI B., and WU, Y. (2007) Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization-mass spectrometry. Food Chemistry 102: 1135-1143.CrossRefGoogle Scholar
LIYANA-PATHIRANA, C.M. and SHAHIDI, F. (2007) Antioxidant and free radical scavenging activities of whole wheat and milling fractions. Food Chemistry 101: 1151-1157.CrossRefGoogle Scholar
MA, M.-S., BAE, I.Y., LEE, H.G. and YANG, C.B. (2006) Purification and identification of angiotensin I-converting enzyme inhibitory peptide from buckwheat (Fagopyrum esculentum Moench). Food Chemistry 96(1): 36-42.CrossRefGoogle Scholar
MARCUSE, R. (1962) The effect of some amino acids on the oxidation of linoleic acid and its methyl ester. Journal of the American Oil Chemists Society 39: 97-103.CrossRefGoogle Scholar
MATOBA, N., USUI, H., FUJITA, H. and YOSHIKAWA, M. (1999) A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in a isolated SHR mesenteric artery. FEBS Letter 452: 181-184.CrossRefGoogle Scholar
MIGUEL, M. and ALEIXANDRE, A. (2006) Antihypertensive peptides derived from egg proteins. Journal of Nutrition 136: 1457-1460.CrossRefGoogle ScholarPubMed
MINE, Y. and KOVACS-NOLAN, J. (2006) New insights in biologically active proteins and peptides derived from hen egg. World's Poultry Science Journal 62(1): 87-95.CrossRefGoogle Scholar
MIQUEL, E. and FARRE, R. (2007) Effects and future trends of casein phosphopeptides on zinc bioavailability. Trends in Food Science & Technology 18: 139-143.CrossRefGoogle Scholar
MIZUSHIMA, S., OHSHIGE, K., WATANABE, J., KIMURA, M., KADOWAKI, T., NAKAMURA, Y., TOCHIKUBO, O. and UESHIMA, H. (2004) Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. American Journal of Hypertension 17: 701-706.CrossRefGoogle ScholarPubMed
NAKANO, Y., ANDO, K., NAKAMURA, S., HIRATA, M., YOSHIDA, T. and MATUNAGA, I. (2001) Relationships between lifestyle-related factors and immune parameters in middle-aged male workers. Journal of Occupational Health 43(6): 321-330.CrossRefGoogle Scholar
PANYAM, D. and KILARA, A. (1996) Enhancing the functionality of food proteins by enzymatic modification. Trends in Food Science & Technology 7: 120-125.CrossRefGoogle Scholar
PARK, P.J., JUNG, W.K., NAM, K.S., SHAHIDI, F. and KIM, S.K. (2001) Purification and characterization of antioxidative peptides from protein hydrolysate of lectin-free egg yolk. Journal of the American Oil Chemists Society 78(6): 651-656.CrossRefGoogle Scholar
PELLEGRINI, A., HULSMEIER, A.J., HUNZIKER, P. and THOMAS, U. (2004) Proteolytic fragments of ovalbumin display antimicrobial activity. Biochimica et Biophysica Acta 1672: 76-85.CrossRefGoogle ScholarPubMed
PELLEGRINI, A., THOMAS, U., WIL, P., SCHRANER, E. and VON FELLENBERG, R. (2000) Effect of lysozyme or modified lysozyme fragments on DNA and RNA synthesis and membrane permeability of Echerichia coli. Microbiological Research 155: 69-77.CrossRefGoogle ScholarPubMed
PICOT, S. BORDENAVE, S., , DIDELOT, I., FRUITIER-ARNAUDIN, F., SANNIER, G., THORKELSSON, J.P., BERGE, F., GUE´RARD, A. and CHABEAUD, J.M. (2006) Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines. Biochemistry 4: 1217-1222.Google Scholar
POWERS, J.P.S. and HANCOCK, R.E.W. (2003) The relationship between peptide structure and antibacterial activity. Peptides 24: 1681-1691.CrossRefGoogle ScholarPubMed
QIAN, Z-Y., JOLLS, P., MIGLIORE-SAMOUR, D., SCHOENTGEN, F. and FIAT, A-M. (1995) Sheep K-casein peptides inhibit platelet aggregation. Biochimica et Biophysica Acta 1244: 411-417.CrossRefGoogle ScholarPubMed
RICHMAN, P.G. and MEISTER, A. (1975) Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. Journal of Biological Chemistry 250: 1422-1426.CrossRefGoogle ScholarPubMed
ROSE, D.J., DEMEO, M.T., KESHAVARZIAN, A. and HAMAKER, B.R. (2007) Influence of dietary fiber on inflammatory bowel disease and colon cancer: importance of fermentation pattern. Nutrition Reviews 65: 51-62.CrossRefGoogle ScholarPubMed
SAIGA, A., TANABE, S. and NISHIMURA, T. (2003) Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment. Journal of Agricultural and Food Chemistry 51: 3661-3667.CrossRefGoogle ScholarPubMed
SAKANAKA, S., TACHIBANA, Y., ISHIHARA, N. and JUNEJAJA, L.R. (2004) Antioxidant activity of egg-yolk protein hydrolysates in a linoleic acid oxidation system. Food Chemi stry 86, 99-103.Google Scholar
SCHAAFSMA, G. (2009) Safety of protein hydrolysates, fractions there of and bioactive peptides in human nutrition. European Journal of Clinical Nutrition 63: 1161-1168.CrossRefGoogle ScholarPubMed
SHAHIDI, F., HAN, X. Q. and SYNOWIECKI, J. (1995) Production and characteristics of protein hydrolysates from capelin (Mallotus villosus). Food Chemistry 53: 285-293.CrossRefGoogle Scholar
TSUGE, N., EIKAWA, Y., NOMURA, Y., YAMAMOTO, M. and SUGISAWA, K. (1991) Antioxidative activity of peptides prepared by enzymatic hydrolysis of egg white albumin. Nippon Nogeikagaku Kuishi 65: 1635-1641.CrossRefGoogle Scholar
VINNARS, E. and WILMORE, D. (2003) History of parenteral nutrition. Journal of Parenteral and Enteral Nutrition 27: 225-232.CrossRefGoogle ScholarPubMed
VIOQUE, J., SA´NCHEZ-VIOQUE, R., CLEMENTE, A., PEDROCHE, J., BAUTISTA, J. and MILLAN, F. (1999) Production and characterization of an extensive rapeseed protein hydrolysate. Journal of the American Oil Chemists Society 76: 819-23.CrossRefGoogle Scholar
WATANABE, K., TSUGE, Y., SHIMOYAMADA, M., OGAMA, N. and EBINA, T. (1998) Antitumour effects of pronase-treated fragments, glycopeptides, from ovomucin in hen egg white in a double grafted tumour system. Journal of Agricultural and Food Chemistry 46(8): 3033-3038.CrossRefGoogle Scholar
XU, X., KATAYAMA, S. and MINE, Y. (2007) Antioxidant activity of tryptic digest of hen egg yolk phosvitin. Journal of the Science of Food and Agriculture 87: 2604-2608.CrossRefGoogle ScholarPubMed
ZHU, K.X., ZHOU, H.M. and QIAN, H.F. (2006) Antioxidant and free radical scavenging activities of wheat germ protein hydrolysates (WGPH) prepared with alcalase. Process Biochemistry 41: 1296-1302.CrossRefGoogle Scholar