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Role of stem cell factor in somatic–germ cell interactions during prenatal oogenesis

Published online by Cambridge University Press:  26 September 2008

Massimo De Felici ,
Anna Di Carlo  and
Maurizio Pesce
Massimo De Felici*
Affiliation:
Dipartimento di sanità pubblica e Biologia Cellulare, Università di Roma ‘Tor Vergata’, Rome, Italy.
Anna Di Carlo
Affiliation:
Dipartimento di sanità pubblica e Biologia Cellulare, Università di Roma ‘Tor Vergata’, Rome, Italy.
Maurizio Pesce
Affiliation:
Dipartimento di sanità pubblica e Biologia Cellulare, Università di Roma ‘Tor Vergata’, Rome, Italy.
*
Massimo De Felici, Dipartmento di Sanità, Via O. Raimondo, 0173 Rome, Italy.
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Extract

During embryogenesis germ cells originate from primordial germ cells (PGCs). The development of mammalian PGCs involves a number of complex events (formation and segregation of PGC precursors, PGC migration and proliferation) which lead to the differentiation of oocytes or prospermatogonia (for a review see De Felici et al., 1992). During recent years developments in methods for isolation, purification and culture of mouse PGCs have led to significant progress in the understanding of molecular mechanisms of migration, proliferation and differentiation of these cells (for reviews see De Felici, 1994; and De Felici & Pesce, 1994a). In this paper we describe the key role played by stem cell factor (SCF) in PGC development and early folliculogenesis.

Type
Article
Information
Zygote , Volume 4 , Issue 4 , November 1996 , pp. 349 - 351
Copyright
Copyright © Cambridge University Press 1996

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References

Besmer, P. (1991). The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Curr. Opin. Cell Biol. 3, 939– 46.CrossRefGoogle ScholarPubMed
De Felici, M. (1994). Isolation and culture of germ cells from the mouse embryo. In Cell Biology: A Laboratory Handbook, ed. Celis, E., 68–80. New York: Academic Press.Google Scholar
De Felici, M. & McLaren, A. (1992). in vitro culture of mouse promordial germ cells. Exp. Cell. Res. 144, 417–27.CrossRefGoogle Scholar
De Felici, M. & Pesce, M. (1994 a). Growth factors in mouse primordial germ cell migration and proliferation. Prog. Growth Fact. Res. 5, 135–43.CrossRefGoogle ScholarPubMed
De Felici, M. & Pesce, M. (1994 b). Interactions between migratory primordial germ cells and cellular substrates in the mouse. In Germline Development, Ciba Foundation Symposium 182. 140&53. Chichester:Wiley.CrossRefGoogle Scholar
De Felici, M., Dolci, S. & Pesce, M. (1992). Cellular and molecular aspects of mouse primordial germ cell migration and proliferation in culture. Int. J. Dev. Biol. 36, 205–18.Google ScholarPubMed
Horie, K., Takakura, K., Taii, S., Narimoto, K., Noda, Y., Nishikawa, S., Nakayama, H., Fujita, J. & Mori, T. (1991). The expression of c-kit protein during oogenesis and early embryonic development. Biol. Reprod. 45, 547–52.CrossRefGoogle ScholarPubMed
Huang, E.J., Nocka, K.H., Buck, J. & Besmer, P. (1992). Differential expression and processing of two cell associated forms of the Kit-Ligand: KL-1 and KL-2. Mol. Biol. Cell 3, 349–62.CrossRefGoogle ScholarPubMed
Manova, K., Nocka, K., Besmer, P. & Bachvarova, R.F. (1990). Gonadal expression of c-kit encoded at the W locus of the mouse. Development 110, 1057–69.CrossRefGoogle Scholar
Manova, K., Huang, E.J., Angeles, M., De Leon, V., Sanchez, S., Pronovost, S., Besmer, P. & Bachvarova, R.F (1993). The expression pattern of the c-kitligand in gonads of mice supports a role for c-kit receptor in oocyte growth and in proliferation of spermatogonia. Dev. Biol. 157, 85–99.CrossRefGoogle ScholarPubMed
Orr&Urtreger, A., Avivi, A., Zimmer, Y., Givol, D., Yarden, Y. & Lonai, P. (1990). Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development 109, 911–23.CrossRefGoogle Scholar
Pesce, M. & De Felici, M. (1994). Apoptosis in mouse primordial germ cells: a study by transmission and scanning electron microscope. Anat. Embryol. 189, 435–40.CrossRefGoogle ScholarPubMed
Pesce, M., Farrace, M.G., Dolci, S., Piacentini, M. & De Felici, M. (1993). Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis). Development. 118, 1089–94.CrossRefGoogle ScholarPubMed