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A molecular Pathway Analysis Stresses the Role of Inflammation Towards Cognition in Schizophrenia

Published online by Cambridge University Press:  23 March 2020

E.K. Fischer ,
C. Holm ,
M. Christensen  and
A. Drago
E.K. Fischer
Affiliation:
Psykiatrisk Forskningsenhed Vest, Forskningsenheden, Herning, Denmark
C. Holm
Affiliation:
Via University College, Herning, Denmark
M. Christensen
Affiliation:
Via University College, Herning, Denmark
A. Drago
Affiliation:
Psykiatrisk Forskningsenhed Vest, Forskningsenheden, Herning, Denmark

Abstract

Background

Cognitive processes are impaired in Schizophrenia (SKZ). The nature of such impairment escapes definition.

Aim

Identification of a genetic profile at risk of cognitive impairment.

Object

Identifying a molecular pathways enriched for mutations associated with cognitive impairment.

Methods

Seven hundred and sixty-five individuals from the CATIE, M = 556, mean age = 40.93 ± 11.03 were included. Verbal memory was outcome. R and Plink served for the analyses. Inflation factor was controlled by lambda values. Input for the pathway analysis were SNPs associated with outcome (P < 0.05) genomewide.

Results

Gender (male, P = 2.34e–05;t = –4.26) and years of education (P = 1.57e–03;t = 6.502) were associated with verbal memory. Inflammation and oxidation were associated with outcome (Table 1, adj_P < 0.01).

Conclusions

Being male and poorly educated were associated with poorer verbal memory. Inflammation and the arachidonic acid pathway were enriched in mutations associated with poorer verbal memory. This finding is in line with previous reports [1,2,3].

Type
e-Poster walk: Genetics & molecular neurobiology and neuroscience in psychiatry
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S164 - S165
Copyright
Copyright © European Psychiatric Association 2017

Table 1 Pathways enriched in association with verbal memory.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

References

Hoffman, D.R., et al.Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 151–15810.1016/j.plefa.2009.05.003CrossRefGoogle ScholarPubMed
Okaichi, Y., Ishikura, Y., et al.Arachidonic acid improves aged rats’ spatial cognition. Physiol Behav 2005; 84: 617–62310.1016/j.physbeh.2005.02.008CrossRefGoogle ScholarPubMed
Cabrera, B., M., , et al.Cognition and psychopathology in first-episode psychosis: are they related to inflammation? Psychol Med 2016; 46: 2133–214410.1017/S0033291716000659CrossRefGoogle ScholarPubMed
Figure 0

Table 1 Pathways enriched in association with verbal memory.

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