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EPA-1455 - Reward Anticipation in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Published online by Cambridge University Press:  15 April 2020

U. Volpe ,
A. Mucci ,
G.M. Plescia ,
V. Montefusco ,
P. Romano ,
D. Dima ,
O. Gallo ,
A. Soricelli ,
P. Bucci  and
S. Frangou
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U. Volpe
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
A. Mucci
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
G.M. Plescia
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
V. Montefusco
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
P. Romano
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
D. Dima
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA
O. Gallo
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
A. Soricelli
Affiliation:
Department of Studies of Institutions and Territorial Systems, University of Naples Parthenope and IRCCS Research Institute SDN, Naples, Italy
P. Bucci
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
S. Frangou
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA
A. Prinster
Affiliation:
Icahn School of Medicine at Mount Sinai, National Research Council, Naples, Italy
M. Salvatore
Affiliation:
Department of Biomorphological and Functional Studies, University of Naples “Federico II”, Naples, Italy
M. Maj
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy
S. Galderisi
Affiliation:
Department of Psychiatry, Second University of Naples SUN, Naples, Italy

Abstract

Introduction

Previous studies have reported that patient with schizophrenia have preserved hedonic capacity, but impaired ability to anticipate future reward (anticipatory anhedonia) that, according to some authors, may underlie other aspects of negative symptoms, such as avolition.

Objectives/Aims

The aim of our study was to demonstrate an impairment of reward anticipation in patients with deficit schizophrenia (DS), characterized by primary and persistent negative symptoms, but not in those with non-deficit schizophrenia (NDS) with respect to healthy controls (HC), by means of functional magnetic resonance imaging (fMRI).

Methods

fMRI was recorded during the execution of the ’Monetary Incentive Delay’ task in 11 patients with DS, 23 patients with NDS and 23 HC, during the anticipation of five different outcomes, small (SR) or large (LR) reward, small (SP) or large (LP) punishment or no-outcome (NO).

Results

The ventral striatum response to reward anticipation was preserved in subjects with schizophrenia. Only patients with DS, compared with HC, showed a significant reduction in the left caudate during the anticipation of reward. The reduced activity of the caudate correlated with the scores for avolition but not for anhedonia.

Conclusion

Our preliminary data suggest an involvement of the caudate in the abnormal processing of reward stimuli in patients with DS and show that avolition and anhedonia are subtended by different functional abnormalities.

Type
E01 - e-Poster Oral Session 01: Schizophrenia
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014

The Authors thank Compagnia di San Paolo-Neuroscience Call that funded the project ’Reward system and primary negative symptoms in schizophrenia’

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