Let R be a d-dimensional regular local ring of characteristic p > 0 with maximal ideal $\mathfrak m$, let I be an ideal of R and let A = R/I. We describe some properties of the local cohomology module HiI(R), in particular its vanishing, in terms of the Frobenius action on the local cohomology module $H^{d-i}_{\mathfrak m}(A)$.