A prime Goldie ring K, in which each finitely generated left ideal is principal is the endomorphism ring E(F, A) of a free module A, of finite rank, over an Ore domain F. We determine necessary and sufficient conditions to insure that whenever K ≅ E(F, A) ≅ E(G, B) (with A and B free and finitely generated over domains F and G) then (F, A) is semi-linearly isomorphic to (G, B). We also show, by example, that it is possible for K ≅ E(F, A ) ≅ E(G, B), with F and G, not isomorphic.