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1 results

  • Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison

  • J Li, L Yu, R Xia, F Gao, W Luo, Y Jing
  • Journal:
    The Journal of Laryngology & Otology / Volume 127 / Issue 3 / March 2013
    Published online by Cambridge University Press:
    14 February 2013, pp. 239-245
    Print publication:
    March 2013
  • Background:

    To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model.

    Methods:

    Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values.

    Results:

    Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal–time curve (from pre-injection to the last time point) (p < 0.05).

    Conclusion:

    Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.