In this article, I will consider the moral issues that might arise from the possibility of creating more complex and sophisticated autonomous intelligent machines or simply artificial intelligence (AI) that would have the human capacity for moral reasoning, judgment, and decision-making, and (the possibility) of humans enhancing their moral capacities beyond what is considered normal for humanity. These two possibilities raise an urgency for ethical principles that could be used to analyze the moral consequences of the intersection of AI and transhumanism. In this article, I deploy personhood-based relational ethics grounded on Afro-communitarianism as an African ethical framework to evaluate some of the moral problems at the intersection of AI and transhumanism. In doing so, I will propose some Afro-ethical principles for research and policy development in AI and transhumanism.