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Fourth-century Antioch was an outstanding centre of biblical scholarship and of ecclesiastical confusion. The leading figures of the Antiochene school of biblical scholarship in the fourth century were staunch upholders of the faith of Nicaea. Diodore was the leading figure of the school in the middle of the century and bishop of Tarsus from 378. Theodore of Mopsuestia draws a distinction between the office of the exegete and that of the preacher in the introduction to his Commentary on John. For Theodore, the primary author of all scripture was the Holy Spirit. His work of commentary on the Psalms and on the minor prophets led him to pay more attention than the majority of early writers to the precise nature of inspiration. His judgement on New Testament commentaries is based wholly on the suitability of the sense of the disputed reading. Theodore's commentaries on the Old Testament show him as a scholar capable of acute historical observation.
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