The Arctic region is commonly seen as a territory of international dialogue and cooperation. This perception is largely due to the science diplomacy efforts that are largely being contributed by universities, scientific centres, research teams and individual scholars. This paper discusses the Arctic science diplomacy initiatives proposed by Russia’s northernmost federal university. Of particular interest is the case of establishing in the Arctic Zone of the Russian Federation of national biological monitoring network – the initiative supported by the government-funded mega-grant programme. Our analysis suggests that two pillars of science diplomacy – “science for diplomacy” and “diplomacy for science” – can be successfully combined within the framework of one project. Evidence is provided of the pursuit of national interests being not a limiting factor but rather a driver in the process of promoting diplomatic collaborations in science, serving as a third science diplomacy pillar. Significant progress towards ensuring peace and harmony in the Arctic and sustaining international dialogue on science-based responses to global challenges has been achieved through science diplomacy initiatives proposed by Northern (Arctic) Federal University (NArFU). The authors confirm that most effective tools for establishing good neighbourly relations in the Arctic and promoting international cooperation are offered by scientific discussion.