Localization is a key move in the history of medicine across cultures, arguably; but a parallel, if not alternative, narrative can be noticed in the Graeco-Roman tradition (and elsewhere), which I have called one of ‘delocalization’, discussed in Chapter 3:namely, the approach to disease, and especially mental disease, in terms of ‘holistic’ impact on the patient. This surfaces most prominently in some authors, but can also be noticed as a matter of discussion of the locus affectus in great thinkers like Galen. In this particular strand of the history of phrenitis the key authors who have reached us are the Roman author of De medicina, Celsus; the Atomist philosopher and doctor Asclepiades; and the thinkers of the Methodist tradition, represented most extensively by Caelius Aurelianus as far as phrenitis is concerned. This chapter surveys the relevant texts by Celsus and Caelius and the fragmentary evidence on Asclepiades, where an important cluster of shared principles emerges: an interest in psychology and in the health of the individual ‘as a whole’, a disregard for the localization of the disease in a specific body part, and of fever as a key pathological indicator, and a strong inclination towards psychotherapeutical and ‘soothing’ measures.